ID   NORM_THEMA              Reviewed;         464 AA.
AC   Q9WZS2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=TM_0815;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD35897.1; -; Genomic_DNA.
DR   PIR; H72331; H72331.
DR   RefSeq; NP_228624.1; NC_000853.1.
DR   RefSeq; WP_010865209.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WZS2; -.
DR   SMR; Q9WZS2; -.
DR   STRING; 243274.THEMA_00575; -.
DR   TCDB; 2.A.66.1.28; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   DNASU; 898483; -.
DR   EnsemblBacteria; AAD35897; AAD35897; TM_0815.
DR   KEGG; tma:TM0815; -.
DR   KEGG; tmw:THMA_0834; -.
DR   PATRIC; fig|243274.18.peg.112; -.
DR   eggNOG; COG0534; Bacteria.
DR   InParanoid; Q9WZS2; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164243"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  51054 MW;  65DA15D7DE038461 CRC64;
     MRYSLFKNYL PKEEVPEIRK ELIKLALPAM GENVLQMLFG MADTAFLGHY SWKAMSGVGL
     SNQVFWVVQV VLIAASMGAT VTIANAIGAG NRKAVRSLAW NSVFLAIFTG VILTALTPLS
     DVLINIFPNL EGEIESSAKE YLKVILSGSM GFSIMAVFSA MLRGAGDTRT PMIVTGLTNF
     LNIFLDYAMI FGKFGFPEMG VRGAAVATIL SRFVGAGILT YVIFKREEFQ LRKGLVPPKW
     SSQKEILRVG FPTAIENFVF STGVLMFANI LLIAGAEAYA GHRIGINVES LSFMPAFGIS
     VAITTLVGRY NGMGNKEHVL GVIRQGWILS LLFQVTVGII IFLFPEPLIR IFTSDPQIIE
     ISKLPVKIIG LFQFFLAIDS TMNGALRGTG NTLPPMIITF ISIWTARLPV AFVMVKYFQL
     GLLGAWIGMI ADIIFRSTLK LLFFLSGKWE KRAVLTRERV KELG