ID   NORM_VIBVU              Reviewed;         456 AA.
AC   Q8D9N8;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
DE   AltName: Full=Na(+)/drug antiporter;
GN   Name=norM; OrderedLocusNames=VV1_2559;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump that functions as a Na(+)/drug
CC       antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO10910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016795; AAO10910.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043921033.1; NC_004459.3.
DR   AlphaFoldDB; Q8D9N8; -.
DR   SMR; Q8D9N8; -.
DR   PRIDE; Q8D9N8; -.
DR   EnsemblBacteria; AAO10910; AAO10910; VV1_2559.
DR   KEGG; vvu:VV1_2559; -.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Multidrug resistance protein NorM"
FT                   /id="PRO_0000164247"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49248 MW;  57599DE4379AEAE7 CRC64;
     MHRYKKEASN LIKLATPVLI ASVAQTGMGF VDTVMAGGVS ATDMAAVSVA ASIWLPSILF
     GIGLLMALVP VVAQLNGAGK REQVPFEIQQ GAVMALLISI PIIGVLFQTQ WILGYMNVDA
     VMATKTIGYI HAVMFAVPAF LLFQTLRSLT DGLSLTKPAM VIGFIGLLLN IPLNWMFVYG
     KLGAPALGGV GCGVATAIVY WIMFLLLLFY VTTSHRLRQV QLFTTFHPPQ LNAQVKLFKL
     GFPVAAALFF EVTLFAVVAL LVAPLGSTVV AAHQVAINFS SLVFMLPMSI GAATSIRVGH
     MLGEKSTEGA RIASHVGILV GLSTAVFTAL LTVILREQIA LLYTDNRVVI TLAMQLLIFT
     AIYQCTDAIQ VIAAGALRGY KDMRAIFNRT FIAYWLLGLP TGYVLGLTDW IVEPMGAQGF
     WIGFIVGLSS AAAMLGVRLH WLHRQNDEIQ LNYEAR