ID   NORM_VIBVY              Reviewed;         456 AA.
AC   Q7MKP8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
DE   AltName: Full=Na(+)/drug antiporter;
GN   Name=norM; OrderedLocusNames=VV1730;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Multidrug efflux pump that functions as a Na(+)/drug
CC       antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC94494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000037; BAC94494.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011150316.1; NC_005139.1.
DR   AlphaFoldDB; Q7MKP8; -.
DR   SMR; Q7MKP8; -.
DR   STRING; 672.VV93_v1c16220; -.
DR   EnsemblBacteria; BAC94494; BAC94494; BAC94494.
DR   KEGG; vvy:VV1730; -.
DR   PATRIC; fig|196600.6.peg.1705; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Multidrug resistance protein NorM"
FT                   /id="PRO_0000164248"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49148 MW;  F32DBE64D562196A CRC64;
     MHRYKKEASS LIKLATPVLI ASVAQTGMGF VDTVMAGGVS ATDMAAVSVA ASIWLPSILF
     GIGLLMALVP VVAQLNGAGK REQVPFEIQQ GAVMALLISI PIIGVLFQTQ WILGYMNVDA
     VMATKTIGYI HAVMFAVPAF LLFQTLRSLT DGLSLTKPAM VIGFIGLLLN IPLNWMFVYG
     KLGAPALGGV GCGVATAIVY WIMFLLLLLY VTTSQRLRQV QLFTTFHPPQ LNAQVKLFKL
     GFPVAAALFF EVTLFAVVAL LVAPLGSTVV AAHQVAINFS SLVFMLPMSI GAATSIRVGH
     MLGEKSTEGA RIASHVGILV GLSTAVFTAL LTVILREQIA LLYTDNRVVI TLAMQLLIFA
     AIYQCTDAIQ VIAAGALRGY KDMRAIFNRT FIAYWLLGLP TGYVLGLTDW IVEPMGAQGF
     WIGFIVGLSS AAAMLGVRLH WLHRQNDEIQ LNYEAR