ID   NORM_XANCP              Reviewed;         458 AA.
AC   Q8P4E6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=XCC3762;
OS   Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB
OS   528 / LMG 568 / P 25).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=190485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25;
RX   PubMed=12024217; DOI=10.1038/417459a;
RA   da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA   Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr.,
RA   Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA   Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA   Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA   Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA   Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA   Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA   Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA   Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA   Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A.,
RA   Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA   Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA   Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT   "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT   specificities.";
RL   Nature 417:459-463(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE008922; AAM43019.1; -; Genomic_DNA.
DR   RefSeq; NP_639107.1; NC_003902.1.
DR   RefSeq; WP_011038844.1; NC_003902.1.
DR   AlphaFoldDB; Q8P4E6; -.
DR   SMR; Q8P4E6; -.
DR   STRING; 340.xcc-b100_3944; -.
DR   EnsemblBacteria; AAM43019; AAM43019; XCC3762.
DR   KEGG; xcc:XCC3762; -.
DR   PATRIC; fig|190485.4.peg.4025; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   Proteomes; UP000001010; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..458
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164250"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  48168 MW;  F102B32973E61873 CRC64;
     MSVPHSSPSA TPRFAAEVRT TGLLALPLVL GHVSTGLIGF VDNVIAGHHG TATLAAVTIG
     TSLLWLPMLV PIGTLISLTA SVSQLVGAGR EREIGPLFRQ ALWLSLGLGA LMFGFLTAVP
     PLLPTFGIAP DIVPGATDFL HAVRWGGPAL TFYFCMRYLS EGMHWTLPTM LLGFGGLLVL
     APLGYVLTYG KFGFAEHGAQ GLGMASAITM WVQAIAFALY LWRSRRFAHL ELFTHLEGPR
     WRAIGELLRT GLPIGITVLM EGGLFIVTAL LIGRLGSTEA AAHQIAINVS QLCFMIPMGV
     AEATTVRVGH AVGRGDPLGM RRAAWAGYAI VLGTQAVSAS ILLLGHDAIV GVYTNDAAVA
     ALASVLLLFA ATFQFPDGIQ VLSAGALRGL KDTRVPMFLA MFSYWGLGMP LGAGLGLGLG
     WGPQGMWIGL ILGLTAAAIL MGLRFRQTSR RLTAGAAP