NORR_AERHH
ID NORR_AERHH Reviewed; 508 AA.
AC A0KEJ0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Anaerobic nitric oxide reductase transcription regulator NorR {ECO:0000255|HAMAP-Rule:MF_01314};
GN Name=norR {ECO:0000255|HAMAP-Rule:MF_01314}; OrderedLocusNames=AHA_0118;
OS Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=380703;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC 2358 / NCIMB 9240 / NCTC 8049;
RX PubMed=16980456; DOI=10.1128/jb.00621-06;
RA Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL J. Bacteriol. 188:8272-8282(2006).
CC -!- FUNCTION: Required for the expression of anaerobic nitric oxide (NO)
CC reductase, acts as a transcriptional activator for at least the norVW
CC operon. Activation also requires sigma-54. {ECO:0000255|HAMAP-
CC Rule:MF_01314}.
CC -!- PATHWAY: Nitrogen metabolism; nitric oxide reduction.
CC {ECO:0000255|HAMAP-Rule:MF_01314}.
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DR EMBL; CP000462; ABK35919.1; -; Genomic_DNA.
DR RefSeq; WP_011704146.1; NC_008570.1.
DR RefSeq; YP_854649.1; NC_008570.1.
DR AlphaFoldDB; A0KEJ0; -.
DR SMR; A0KEJ0; -.
DR STRING; 380703.AHA_0118; -.
DR PRIDE; A0KEJ0; -.
DR EnsemblBacteria; ABK35919; ABK35919; AHA_0118.
DR KEGG; aha:AHA_0118; -.
DR PATRIC; fig|380703.7.peg.111; -.
DR eggNOG; COG3604; Bacteria.
DR HOGENOM; CLU_000445_125_0_6; -.
DR OMA; LRYEAHQ; -.
DR UniPathway; UPA00638; -.
DR Proteomes; UP000000756; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01314; NorR; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR023944; NorR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00065; GAF; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..508
FT /note="Anaerobic nitric oxide reductase transcription
FT regulator NorR"
FT /id="PRO_0000305616"
FT DOMAIN 186..415
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT DNA_BIND 483..502
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 214..221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 277..286
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT MOD_RES 56
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
SQ SEQUENCE 508 AA; 55065 MW; A53D06D5653CFFD9 CRC64;
MISTDSLARI ALDLQLGISH QDRFHRLIQS VRSLLNSDAS ALLRYEGGQF IPLAIDGLMQ
DVLGRRFALK DHPRMEAIAR AGDVVRFPAD SSLPDPYDGL LPDHDDFKVH ACVGLPLFSD
QALIGALTID GMNPTQFDAI SDEELRLVGA LAAAALNNAL LLERLARQSS EPLVPGTRPG
PEQPEMIGQS PAMARLRHEI EVVANSELNV LILGETGVGK ELIAKAVHRG SQRAKAPLVY
LNCAALPESV AESELFGHVK GAFTGAIHNR AGKFELADQG TLFLDEIGEL SLPLQAKLLR
VLQYGDLQRI GDDTPLKVNV RILAATNRDL KQAVVEGQFR ADLYHRLSVF PIHAPALRER
PGDIPLLAGY FCERCRLSLG LEQLRIQPQA LQLLERHDWP GNVRELEHAI HRAAVLARAE
QGSQTPTLAS HHFNLAAGPL PPSTSPAMAP MTPLPGGLGL RAATDAFQLA LIEQTLAAHN
GNWAATARAL ELDSGNLHRL AKRLGLKA