NORR_ECOUT
ID NORR_ECOUT Reviewed; 504 AA.
AC Q1R7Z1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Anaerobic nitric oxide reductase transcription regulator NorR {ECO:0000255|HAMAP-Rule:MF_01314};
GN Name=norR {ECO:0000255|HAMAP-Rule:MF_01314}; OrderedLocusNames=UTI89_C3071;
OS Escherichia coli (strain UTI89 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=364106;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTI89 / UPEC;
RX PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA Gordon J.I.;
RT "Identification of genes subject to positive selection in uropathogenic
RT strains of Escherichia coli: a comparative genomics approach.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC -!- FUNCTION: Required for the expression of anaerobic nitric oxide (NO)
CC reductase, acts as a transcriptional activator for at least the norVW
CC operon. Activation also requires sigma-54. {ECO:0000255|HAMAP-
CC Rule:MF_01314}.
CC -!- PATHWAY: Nitrogen metabolism; nitric oxide reduction.
CC {ECO:0000255|HAMAP-Rule:MF_01314}.
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DR EMBL; CP000243; ABE08523.1; -; Genomic_DNA.
DR RefSeq; WP_000010727.1; NC_007946.1.
DR AlphaFoldDB; Q1R7Z1; -.
DR SMR; Q1R7Z1; -.
DR EnsemblBacteria; ABE08523; ABE08523; UTI89_C3071.
DR KEGG; eci:UTI89_C3071; -.
DR HOGENOM; CLU_000445_125_0_6; -.
DR OMA; LRYEAHQ; -.
DR UniPathway; UPA00638; -.
DR Proteomes; UP000001952; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01314; NorR; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR023944; NorR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00065; GAF; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein;
KW Transcription; Transcription regulation.
FT CHAIN 1..504
FT /note="Anaerobic nitric oxide reductase transcription
FT regulator NorR"
FT /id="PRO_0000305619"
FT DOMAIN 187..416
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT DNA_BIND 479..498
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 215..222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 278..287
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT MOD_RES 57
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
SQ SEQUENCE 504 AA; 55186 MW; 7A0FEB53E863FE5A CRC64;
MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ FIPLAIDGLA
KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG LIPGQESLKV HACVGLPLFA
GQNLIGALTL DGMQPDQFDV FSDEELRLIA ALAAGALSNA LLIEQLESQN MLPGDAAPFE
AVKQTQMIGL SPGMTQLKKE IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV
YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL
RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLSVPPLRE
RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF PGNVRELEHA IHRAVVLSRA
TRSGDEVILE AQHFAFPEVT LPPPEAAAVP VVKQNLREAT EAFQRETIRQ ALAQNHHNWA
ACARMLETDV ANLHRLAKRL GLKD