NORR_SALTY
ID NORR_SALTY Reviewed; 506 AA.
AC Q8ZMJ8;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Anaerobic nitric oxide reductase transcription regulator NorR {ECO:0000255|HAMAP-Rule:MF_01314};
GN Name=norR {ECO:0000255|HAMAP-Rule:MF_01314}; OrderedLocusNames=STM2839;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Required for the expression of anaerobic nitric oxide (NO)
CC reductase, acts as a transcriptional activator for at least the norVW
CC operon. Activation also requires sigma-54. {ECO:0000255|HAMAP-
CC Rule:MF_01314}.
CC -!- PATHWAY: Nitrogen metabolism; nitric oxide reduction.
CC {ECO:0000255|HAMAP-Rule:MF_01314}.
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DR EMBL; AE006468; AAL21719.1; -; Genomic_DNA.
DR RefSeq; NP_461760.1; NC_003197.2.
DR RefSeq; WP_000010814.1; NC_003197.2.
DR AlphaFoldDB; Q8ZMJ8; -.
DR SMR; Q8ZMJ8; -.
DR STRING; 99287.STM2839; -.
DR PaxDb; Q8ZMJ8; -.
DR EnsemblBacteria; AAL21719; AAL21719; STM2839.
DR GeneID; 1254362; -.
DR KEGG; stm:STM2839; -.
DR PATRIC; fig|99287.12.peg.2993; -.
DR HOGENOM; CLU_000445_125_2_6; -.
DR OMA; LRYEAHQ; -.
DR PhylomeDB; Q8ZMJ8; -.
DR BioCyc; SENT99287:STM2839-MON; -.
DR UniPathway; UPA00638; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01314; NorR; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR023944; NorR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00065; GAF; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..506
FT /note="Anaerobic nitric oxide reductase transcription
FT regulator NorR"
FT /id="PRO_0000081157"
FT DOMAIN 187..416
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT DNA_BIND 481..500
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 215..222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT BINDING 278..287
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
FT MOD_RES 57
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01314"
SQ SEQUENCE 506 AA; 55375 MW; D0F695A6A2DC966D CRC64;
MSFSVEVLAG IAIELQRGIG HQDRFQRLIT TLRQVLACDA SALLRYESRQ FIPLAIDGLA
QDVLGRRFTL EGHPRLEAIA RAGDVVRFPA DSDLPDPYDG LIPGQESLKV HACVGLPLFA
GQNLIGALTL DAMTPEQFEV FSDEELRLVA ALAAGALSNA LLIEQLESQN MLPGSSGVFE
PIKETHMIGL SPAMTQLKKE IEIVAGSDLN VLIGGETGTG KELVAKAIHQ GSPRAVNPLV
YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL
RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLFVPPLRE
RGDDVVLLAG YFCEQCRLRL GLSRVVLSPG ARRHLLNYGW PGNVRELEHA IHRAVVLARA
TRAGDEVILE AQHFALSEDV LPAPPAESFL ALPTCRNLRE STENFQREMI RQALAQNNHN
WAASARALET DVANLHRLAK RLGLKD