ID   NOSA_ASPFU              Reviewed;         685 AA.
AC   Q4WPL7;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=C6 finger domain transcription factor nosA {ECO:0000305};
GN   Name=nosA {ECO:0000303|PubMed:23022264}; ORFNames=AFUA_4G09710;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   INDUCTION.
RX   PubMed=17432932; DOI=10.1371/journal.ppat.0030050;
RA   Perrin R.M., Fedorova N.D., Bok J.W., Cramer R.A., Wortman J.R., Kim H.S.,
RA   Nierman W.C., Keller N.P.;
RT   "Transcriptional regulation of chemical diversity in Aspergillus fumigatus
RT   by LaeA.";
RL   PLoS Pathog. 3:E50-E50(2007).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23022264; DOI=10.1016/j.fgb.2012.09.005;
RA   Soukup A.A., Farnoodian M., Berthier E., Keller N.P.;
RT   "NosA, a transcription factor important in Aspergillus fumigatus stress and
RT   developmental response, rescues the germination defect of a laeA
RT   deletion.";
RL   Fungal Genet. Biol. 49:857-865(2012).
CC   -!- FUNCTION: Transcription factor that mediates stress and developmental
CC       response. {ECO:0000269|PubMed:23022264}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is repressed by laeA.
CC       {ECO:0000269|PubMed:17432932}.
CC   -!- DISRUPTION PHENOTYPE: Increases radial growth, remediates the
CC       germination defect of a laeA deletion, and increases virulence in the
CC       G. mellonella model of invasive aspergillosis.
CC       {ECO:0000269|PubMed:23022264}.
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DR   EMBL; AAHF01000005; EAL89817.2; -; Genomic_DNA.
DR   RefSeq; XP_751855.2; XM_746762.2.
DR   AlphaFoldDB; Q4WPL7; -.
DR   SMR; Q4WPL7; -.
DR   STRING; 746128.CADAFUBP00006502; -.
DR   EnsemblFungi; EAL89817; EAL89817; AFUA_4G09710.
DR   GeneID; 3509300; -.
DR   KEGG; afm:AFUA_4G09710; -.
DR   VEuPathDB; FungiDB:Afu4g09710; -.
DR   eggNOG; ENOG502RX7Y; Eukaryota.
DR   HOGENOM; CLU_011522_0_0_1; -.
DR   InParanoid; Q4WPL7; -.
DR   OMA; PFNMTLT; -.
DR   OrthoDB; 411827at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF11951; Fungal_trans_2; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..685
FT                   /note="C6 finger domain transcription factor nosA"
FT                   /id="PRO_0000435649"
FT   DNA_BIND        49..76
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          626..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..664
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  76481 MW;  E15C92CB30EAE9E0 CRC64;
     MPVASRKKSS ASNAAKRVDS TQSPSPGEEV SIGTPEKAPK LHKRSRSGCF TCRLRRKKCD
     EKHPACGACS NLCVKCEYKR PIWWGNAEQR RIQKERIKNK IKQTKMNERN GSATDPLARS
     RNMAATSPLS PVFDFNRPGH TETYDLFSSH LPTPGLNQTM YAPYAPYEID VKTERQTFIN
     DVPLRHDSSI STFSTFTAPQ LSAPLPTFPS EDWLQDEYFS QAPNLSGIDP AICEQSFGQT
     YTTLQSNIPV SDHDRPLLDH FIHNVLRIIF PVLEAHQRGH TRAQAILQAL ETNKCYLHCC
     LSVAAIHLKT TEGFVGEQID HDIMRHRFEA VSHLCQALSE DINHEEILDA TLAMIFFHCS
     VGPADDYLPD IPWFDHFQAA SNLVNRLGLP TAVPEGNPYV LPPFSMTLTS WIDILGSTMQ
     GRTPQFAHTY RAKHLSGSSS GLRELMGCDD RVMYLISEIT CLDALKTEGR IDAMAVCSHV
     SALGRQLEFT EPVDQTLEHP FSPTTGAIRP EILTKNMTTV FRIAARIYLC SLVPGFDRNQ
     PSNLNLVAAV ANTLNYIPSG PNGFDRSLVW PLLITGAFSA PTSQFRAVLA ERASLLGDHA
     DLGSFGRMYR LLQEVWRLTD DPADSYYTPE ETSSSSASSG SPVPKIERSA SPESNSTGSS
     MREIKKQQVH WRDVMQRNGW HYLLI