ID   NOSIP_CAEEL             Reviewed;         310 AA.
AC   Q21755;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Nitric oxide synthase-interacting protein homolog;
GN   ORFNames=R05G6.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Negatively regulates nitric oxide production by inducing
CC       nitric oxide synthase translocation to actin cytoskeleton and
CC       inhibiting its enzymatic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOSIP family. {ECO:0000305}.
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DR   EMBL; FO081426; CCD71554.1; -; Genomic_DNA.
DR   PIR; T29358; T29358.
DR   RefSeq; NP_501214.1; NM_068813.6.
DR   AlphaFoldDB; Q21755; -.
DR   STRING; 6239.R05G6.4; -.
DR   EPD; Q21755; -.
DR   PaxDb; Q21755; -.
DR   PeptideAtlas; Q21755; -.
DR   EnsemblMetazoa; R05G6.4.1; R05G6.4.1; WBGene00019898.
DR   GeneID; 177526; -.
DR   KEGG; cel:CELE_R05G6.4; -.
DR   UCSC; R05G6.4; c. elegans.
DR   CTD; 177526; -.
DR   WormBase; R05G6.4; CE07417; WBGene00019898; -.
DR   eggNOG; KOG3039; Eukaryota.
DR   GeneTree; ENSGT00390000015505; -.
DR   HOGENOM; CLU_053742_0_0_1; -.
DR   InParanoid; Q21755; -.
DR   OMA; AKEKRPM; -.
DR   OrthoDB; 1567031at2759; -.
DR   PhylomeDB; Q21755; -.
DR   PRO; PR:Q21755; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00019898; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR016818; NOSIP.
DR   InterPro; IPR031790; Znf-NOSIP.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13063; PTHR13063; 1.
DR   Pfam; PF15906; zf-NOSIP; 1.
DR   PIRSF; PIRSF023577; ENOS_interacting; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..310
FT                   /note="Nitric oxide synthase-interacting protein homolog"
FT                   /id="PRO_0000280591"
FT   REGION          115..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  33973 MW;  DE82950301897D0B CRC64;
     MTRHGKNSTA ASVYTYHERR RDAKASGYGT LHARLGADSI KEFHCCSLTL QPCRNPVISP
     TGYIFDREAI LENILAQKKA YAKKLKEYEK QVAEESAAAK IAEGQAETFT KRTQFSAIES
     TPSRTGAVAT PRPEVGSLKR QGGVMSTEIA AKVKAHGEEG VMSNMKGDKS TSLPSFWIPE
     LNPTAVATKL EKPSSKVLCP VSGKPIKLKE LLEVKFTPMP GTETAAHRKF LCPVTRDELT
     NTTRCAYLKK SKSVVKYDVV EKLIKGDGID PINGEPMSED DIIELQRGGT GYSATNETKA
     KLIRPQLELQ