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NOT3_CANAL
ID   NOT3_CANAL              Reviewed;         752 AA.
AC   Q5AD56; A0A1D8PG97; Q5ADI5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=General negative regulator of transcription subunit 3;
GN   Name=NOT3; Synonyms=NOT31; OrderedLocusNames=CAALFM_C201130WA;
GN   ORFNames=CaO19.2012, CaO19.9563;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=14500538; DOI=10.1128/iai.71.10.6101-6103.2003;
RA   Cheng S., Nguyen M.H., Zhang Z., Jia H., Handfield M., Clancy C.J.;
RT   "Evaluation of the roles of four Candida albicans genes in virulence by
RT   using gene disruption strains that express URA3 from the native locus.";
RL   Infect. Immun. 71:6101-6103(2003).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA   Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA   Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT   "Portrait of Candida albicans adherence regulators.";
RL   PLoS Pathog. 8:E1002525-E1002525(2012).
CC   -!- FUNCTION: Acts as component of the CCR4-NOT core complex, which in the
CC       nucleus seems to be a general transcription factor, and in the
CC       cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT
CC       protein subcomplex negatively regulates the basal and activated
CC       transcription of many genes. Preferentially affects TC-type TATA
CC       element-dependent transcription. Could directly or indirectly inhibit
CC       component(s) of the general transcription machinery (By similarity).
CC       Required for yeast cell adherence to silicone substrate, but nor
CC       required not required for buccal epithelial cell adherence or virulence
CC       in mouse systemic infection. {ECO:0000250, ECO:0000269|PubMed:14500538,
CC       ECO:0000269|PubMed:22359502}.
CC   -!- SUBUNIT: Component of the NOT protein complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC       Decreases slightly filamentation. {ECO:0000269|PubMed:14500538,
CC       ECO:0000269|PubMed:22359502}.
CC   -!- SIMILARITY: Belongs to the CNOT2/3/5 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27161.1; -; Genomic_DNA.
DR   RefSeq; XP_019330745.1; XM_019475200.1.
DR   AlphaFoldDB; Q5AD56; -.
DR   SMR; Q5AD56; -.
DR   STRING; 237561.Q5AD56; -.
DR   PRIDE; Q5AD56; -.
DR   GeneID; 3638829; -.
DR   KEGG; cal:CAALFM_C201130WA; -.
DR   CGD; CAL0000179957; NOT3.
DR   VEuPathDB; FungiDB:C2_01130W_A; -.
DR   eggNOG; KOG2150; Eukaryota.
DR   HOGENOM; CLU_020483_0_0_1; -.
DR   InParanoid; Q5AD56; -.
DR   OrthoDB; 1109812at2759; -.
DR   PRO; PR:Q5AD56; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR040168; Not2/3/5.
DR   InterPro; IPR007207; Not_N.
DR   PANTHER; PTHR23326; PTHR23326; 1.
DR   Pfam; PF04065; Not3; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..752
FT                   /note="General negative regulator of transcription subunit
FT                   3"
FT                   /id="PRO_0000426088"
FT   REGION          126..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          173..230
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        130..160
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..306
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85707 MW;  7BF3D442F20C4D6F CRC64;
     MSNRKLQKEI DIIFKKIQEG LQDFDYHYER YESIQNTEDD SDNQREKEKL ANDLKKEIKK
     LQKFREQIKH WLQNDTVHTL GPVGTSYESK LAENKSLIED SMETYKLVEK QSKLKTFSNQ
     SIMMTFMDST NGDDDDDDDD SDDDELFSGS DEDEEDEYSD LPEDAVNAIH FFKDSILQLR
     EQTHKLDHEY EKLAAKKLRK NNLATIEAKK EKIQSTIGNN KFHQKKLKKL LRQLTSGVVT
     EFNLIWLLKD DLNKYLESNG DYEFTRETEL YDDIFNQIAA VEEDYSEIHE DNHDHSHSHL
     EKTSTANGTH HESATTTATA AKNSSVTTRT SPSPILTKAN GHIKELSVES GSPTTSRSKL
     SKIHTNTSQS STHSNTSSST HAQAPRQSPE LTSPAIVKTL RPATAPSKPV GTLKWSAAAA
     AAIPDVQEKP ELVETESNGS SVHKTVSKDQ YEEKINYQSP APTQQQQQPQ TSVESKTLST
     TQSLASSITD NINLDKYKEV IKNSNLTKTE LGLFSDMNLA RVPPGIQDLV ISFASKRNND
     NFKVLVDSTE FNQFALPLHK PYLPEIVQPS YYSQYTSTSF KHPTPLVKFQ SYWNQVRANF
     GFQKLMDEIK SLTLQNNADN LPIIAELTFV LFYGFYYGVT PAENLIAESY LFELGWKPYK
     NQSEDGSNNL STGSISLSDI NGSKSKSNRS SNYYFWFKRV KLISRGEDMG QPSNIEFGDY
     QVFDLSFWEI FVKYGFKFDY NFCQMEPSKT LF
 
 
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