NOVA_DROME
ID NOVA_DROME Reviewed; 780 AA.
AC A0A0B4KGY6; A0A0B4JCX5; A0A0B4KFY5; A0A0B4LGY5; A0A0B4LI06; Q0KI94; Q0KI96;
AC Q8INP0; Q8T4D1; Q9GNC8; Q9GQN3; Q9GQN4; Q9VHD4; Q9VHD6;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-2015, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=RNA-binding protein Pasilla {ECO:0000303|PubMed:11784037};
GN Name=ps {ECO:0000312|FlyBase:FBgn0261552};
GN Synonyms=l(3)10615 {ECO:0000312|FlyBase:FBgn0261552},
GN NOVA1 {ECO:0000312|FlyBase:FBgn0261552};
GN ORFNames=CG42670 {ECO:0000312|FlyBase:FBgn0261552};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|EMBL:AAG36789.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE,
RP DISRUPTION PHENOTYPE, AND MUTAGENESIS OF PRO-466.
RX PubMed=11784037; DOI=10.1006/dbio.2001.0429;
RA Seshaiah P., Miller B., Myat M.M., Andrew D.J.;
RT "pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins,
RT is required for normal secretion in the salivary gland.";
RL Dev. Biol. 239:309-322(2001).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAL89985.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM J).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL89985.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AAL89985.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=28525754; DOI=10.1016/j.cell.2017.05.006;
RA Gill J., Park Y., McGinnis J.P., Perez-Sanchez C., Blanchette M., Si K.;
RT "Regulated Intron Removal Integrates Motivational State and Experience.";
RL Cell 169:836-848.e15(2017).
CC -!- FUNCTION: Functions to regulate alternative splicing in neurons by
CC binding pre-mRNA in a sequence-specific manner to activate exon
CC inclusion (By similarity). Plays a role in long-term memory formation
CC by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby
CC controlling Orb2A protein abundance (PubMed:28525754).
CC {ECO:0000250|UniProtKB:Q9JKN6, ECO:0000269|PubMed:28525754}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11784037,
CC ECO:0000269|PubMed:28525754}. Cytoplasm {ECO:0000269|PubMed:28525754}.
CC Note=Localizes to synaptoneuropil region of neurons.
CC {ECO:0000269|PubMed:28525754}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=12;
CC Name=R {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-1; Sequence=Displayed;
CC Name=B {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-9; Sequence=VSP_061142, VSP_061146, VSP_061147;
CC Name=C {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-8; Sequence=VSP_061138;
CC Name=D {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-2; Sequence=VSP_061141;
CC Name=F {ECO:0000312|FlyBase:FBgn0261552}; Synonyms=G
CC {ECO:0000312|FlyBase:FBgn0261552}, H {ECO:0000312|FlyBase:FBgn0261552},
CC N {ECO:0000312|FlyBase:FBgn0261552}, O
CC {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-3; Sequence=VSP_061143;
CC Name=I {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-5; Sequence=VSP_061141, VSP_061146, VSP_061147;
CC Name=J {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-4; Sequence=VSP_061142;
CC Name=L {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-6; Sequence=VSP_061145;
CC Name=M {ECO:0000312|FlyBase:FBgn0261552}; Synonyms=K
CC {ECO:0000312|FlyBase:FBgn0261552}, P {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-7; Sequence=VSP_061140;
CC Name=Q {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-10; Sequence=VSP_061139;
CC Name=S {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-12; Sequence=VSP_061144, VSP_061145;
CC Name=T {ECO:0000312|FlyBase:FBgn0261552};
CC IsoId=A0A0B4KGY6-11; Sequence=VSP_061144;
CC -!- TISSUE SPECIFICITY: Expressed in the central nervous system in mushroom
CC body neurons (at protein level). {ECO:0000269|PubMed:28525754}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the salivary gland, anterior and
CC posterior midgut primordia, the fully formed midgut, amnioserosa,
CC malpighian tubules, several regions of the head, and in isolated cells
CC along the germ band, which are likely to be hemocytes.
CC {ECO:0000269|PubMed:11784037}.
CC -!- DOMAIN: The KH domain consists of approximately 70 amino acids and
CC includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif,
CC and an additional variable segment. The third KH domain (KH3) binds a
CC hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules.
CC RNA binding by KH3 requires residues C-terminal to the KH domain.
CC {ECO:0000250|UniProtKB:P51513}.
CC -!- DISRUPTION PHENOTYPE: In both embryo and larva, results in irregularly
CC shaped salivary glands with bulges of variable sizes, leading to
CC greater distances between neighboring nuclei and decreased apical
CC secretion. {ECO:0000269|PubMed:11784037}.
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DR EMBL; AF220420; AAG36787.1; -; mRNA.
DR EMBL; AF220421; AAG36788.1; -; mRNA.
DR EMBL; AF220422; AAG36789.1; -; mRNA.
DR EMBL; AF220423; AAG36790.1; -; mRNA.
DR EMBL; AE014297; AAF54377.3; -; Genomic_DNA.
DR EMBL; AE014297; AAF54378.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13424.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13425.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13427.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13428.1; -; Genomic_DNA.
DR EMBL; AE014297; ABI31151.1; -; Genomic_DNA.
DR EMBL; AE014297; ABI31152.1; -; Genomic_DNA.
DR EMBL; AE014297; ABI31154.1; -; Genomic_DNA.
DR EMBL; AE014297; ADV37290.1; -; Genomic_DNA.
DR EMBL; AE014297; ADV37291.1; -; Genomic_DNA.
DR EMBL; AE014297; ADV37292.1; -; Genomic_DNA.
DR EMBL; AE014297; ADV37293.1; -; Genomic_DNA.
DR EMBL; AE014297; ADV37294.1; -; Genomic_DNA.
DR EMBL; AE014297; AGB95796.1; -; Genomic_DNA.
DR EMBL; AE014297; AGB95797.1; -; Genomic_DNA.
DR EMBL; AE014297; AHN57251.1; -; Genomic_DNA.
DR EMBL; AE014297; AHN57252.1; -; Genomic_DNA.
DR EMBL; AY089247; AAL89985.1; -; mRNA.
DR RefSeq; NP_001036691.1; NM_001043226.1. [A0A0B4KGY6-5]
DR RefSeq; NP_001036692.1; NM_001043227.2. [A0A0B4KGY6-3]
DR RefSeq; NP_001036695.1; NM_001043230.3. [A0A0B4KGY6-7]
DR RefSeq; NP_001036697.1; NM_001043232.1. [A0A0B4KGY6-4]
DR RefSeq; NP_001189199.1; NM_001202270.2. [A0A0B4KGY6-3]
DR RefSeq; NP_001189200.1; NM_001202271.2. [A0A0B4KGY6-6]
DR RefSeq; NP_001189201.1; NM_001202272.2. [A0A0B4KGY6-7]
DR RefSeq; NP_001189202.1; NM_001202273.2. [A0A0B4KGY6-7]
DR RefSeq; NP_001189203.1; NM_001202274.2. [A0A0B4KGY6-3]
DR RefSeq; NP_001262414.1; NM_001275485.1. [A0A0B4KGY6-10]
DR RefSeq; NP_001262415.1; NM_001275486.1. [A0A0B4KGY6-1]
DR RefSeq; NP_001287252.1; NM_001300323.1. [A0A0B4KGY6-12]
DR RefSeq; NP_001287253.1; NM_001300324.1. [A0A0B4KGY6-11]
DR RefSeq; NP_731351.3; NM_169280.4. [A0A0B4KGY6-3]
DR RefSeq; NP_731352.3; NM_169281.4. [A0A0B4KGY6-3]
DR RefSeq; NP_731354.1; NM_169283.2. [A0A0B4KGY6-9]
DR RefSeq; NP_731355.1; NM_169284.2. [A0A0B4KGY6-2]
DR RefSeq; NP_731356.1; NM_169285.3. [A0A0B4KGY6-8]
DR AlphaFoldDB; A0A0B4KGY6; -.
DR SMR; A0A0B4KGY6; -.
DR IntAct; A0A0B4KGY6; 181.
DR STRING; 7227.FBpp0291831; -.
DR DNASU; 44258; -.
DR EnsemblMetazoa; FBtr0082037; FBpp0081515; FBgn0261552. [A0A0B4KGY6-9]
DR EnsemblMetazoa; FBtr0082038; FBpp0081516; FBgn0261552. [A0A0B4KGY6-2]
DR EnsemblMetazoa; FBtr0082039; FBpp0081517; FBgn0261552. [A0A0B4KGY6-8]
DR EnsemblMetazoa; FBtr0111027; FBpp0110326; FBgn0261552. [A0A0B4KGY6-3]
DR EnsemblMetazoa; FBtr0111028; FBpp0110327; FBgn0261552. [A0A0B4KGY6-3]
DR EnsemblMetazoa; FBtr0111029; FBpp0110328; FBgn0261552. [A0A0B4KGY6-3]
DR EnsemblMetazoa; FBtr0111030; FBpp0110329; FBgn0261552. [A0A0B4KGY6-5]
DR EnsemblMetazoa; FBtr0111031; FBpp0110330; FBgn0261552. [A0A0B4KGY6-4]
DR EnsemblMetazoa; FBtr0111032; FBpp0110331; FBgn0261552. [A0A0B4KGY6-7]
DR EnsemblMetazoa; FBtr0302691; FBpp0291831; FBgn0261552. [A0A0B4KGY6-6]
DR EnsemblMetazoa; FBtr0302692; FBpp0291832; FBgn0261552. [A0A0B4KGY6-3]
DR EnsemblMetazoa; FBtr0302693; FBpp0291833; FBgn0261552. [A0A0B4KGY6-3]
DR EnsemblMetazoa; FBtr0302694; FBpp0291834; FBgn0261552. [A0A0B4KGY6-7]
DR EnsemblMetazoa; FBtr0302695; FBpp0291835; FBgn0261552. [A0A0B4KGY6-7]
DR EnsemblMetazoa; FBtr0334303; FBpp0306418; FBgn0261552. [A0A0B4KGY6-10]
DR EnsemblMetazoa; FBtr0334304; FBpp0306419; FBgn0261552. [A0A0B4KGY6-1]
DR EnsemblMetazoa; FBtr0344283; FBpp0310688; FBgn0261552. [A0A0B4KGY6-12]
DR EnsemblMetazoa; FBtr0344284; FBpp0310689; FBgn0261552. [A0A0B4KGY6-11]
DR GeneID; 44258; -.
DR KEGG; dme:Dmel_CG42670; -.
DR UCSC; CG16765-RB; d. melanogaster.
DR UCSC; CG16765-RC; d. melanogaster.
DR UCSC; CG16765-RG; d. melanogaster.
DR UCSC; CG16765-RJ; d. melanogaster.
DR UCSC; CG16765-RK; d. melanogaster.
DR CTD; 109641; -.
DR FlyBase; FBgn0261552; ps.
DR VEuPathDB; VectorBase:FBgn0261552; -.
DR eggNOG; KOG2191; Eukaryota.
DR GeneTree; ENSGT00940000171065; -.
DR HOGENOM; CLU_022670_1_1_1; -.
DR OMA; MTTLANY; -.
DR OrthoDB; 1167935at2759; -.
DR BioGRID-ORCS; 44258; 1 hit in 3 CRISPR screens.
DR ChiTaRS; ps; fly.
DR GenomeRNAi; 44258; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0261552; Expressed in mouthpart and 62 other tissues.
DR ExpressionAtlas; A0A0B4KGY6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IDA:FlyBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0033120; P:positive regulation of RNA splicing; IDA:FlyBase.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0051252; P:regulation of RNA metabolic process; IBA:GO_Central.
DR Gene3D; 3.30.1370.10; -; 3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR Pfam; PF00013; KH_1; 3.
DR SMART; SM00322; KH; 3.
DR SUPFAM; SSF54791; SSF54791; 3.
DR PROSITE; PS50084; KH_TYPE_1; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..780
FT /note="RNA-binding protein Pasilla"
FT /id="PRO_0000453455"
FT DOMAIN 273..340
FT /note="KH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 366..432
FT /note="KH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 691..758
FT /note="KH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..776
FT /note="Required for RNA binding"
FT /evidence="ECO:0000250|UniProtKB:P51513"
FT COMPBIAS 168..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..270
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHG -> MLFARTTSSTSISP
FT PAMMMQQHQQQQQQQDPQKLGQQFHQQPAFQLQQSFC (in isoform C)"
FT /id="VSP_061138"
FT VAR_SEQ 1..270
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHG -> MRKLCSS (in
FT isoform Q)"
FT /id="VSP_061139"
FT VAR_SEQ 1..269
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHH -> MAEDATMETCPSPET
FT GDSRKRPLDSDPENEQTKRSHFSS (in isoform M)"
FT /id="VSP_061140"
FT VAR_SEQ 1..248
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCYG -> MLFARTTSSTSISPPAMMMQQHQQQQQQQDPQKLGQ
FT QFHQQPAFQLQQSFC (in isoform D and isoform I)"
FT /id="VSP_061141"
FT VAR_SEQ 1..248
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCYG -> MRKLCSS (in isoform J and isoform
FT B)"
FT /id="VSP_061142"
FT VAR_SEQ 1..247
FT /note="MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPE
FT NEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSS
FT SINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPL
FT SENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSN
FT AQQQLQLGNYKTNSCWCY -> MAEDATMETCPSPETGDSRKRPLDSDPENEQTKRSHF
FT SS (in isoform F)"
FT /id="VSP_061143"
FT VAR_SEQ 1..164
FT /note="Missing (in isoform T and isoform S)"
FT /id="VSP_061144"
FT VAR_SEQ 248..269
FT /note="Missing (in isoform L and isoform S)"
FT /id="VSP_061145"
FT VAR_SEQ 709..716
FT /note="PSGRSLVE -> ARPYYYPY (in isoform I and isoform B)"
FT /id="VSP_061146"
FT VAR_SEQ 717..780
FT /note="Missing (in isoform I and isoform B)"
FT /id="VSP_061147"
FT MUTAGEN 466
FT /note="P->L: In both embryo and larva, results in
FT irregularly shaped salivary glands with bulges of variable
FT sizes, leading to greater distances between neighboring
FT nuclei."
FT /evidence="ECO:0000269|PubMed:11784037"
SQ SEQUENCE 780 AA; 81403 MW; 9073B1B1A7081057 CRC64;
MESIMKVAMD KAAEQLIQQF GFDYLQQQLQ LQHQNQHNSS PQQPQHQQLE PENEHLTYQY
QQSKPTHMQQ LACNYQPRHS TTTSSPSSTH SLASGGGSSS NSSNSSSSDS SSINISHISN
ISNISNIGNI SNSNHSNAAY SLAVHSYQKQ IESPANPSHV PHHQMDLSPL SENGSPNGTP
GAQTPTATAS GNTAAALASA AAAAAAATSG GNGSSITNCN SNNSSSSSNA QQQLQLGNYK
TNSCWCYGES VCSGIEVEIE NNNNNHIHHG ETTYHMKILV PAVASGAIIG KGGETIASLQ
KDTGARVKMS KSHDFYPGTT ERVCLITGST EAIMVVMEFI MDKIREKPDL TNKIVDTDSK
QTQERDKQVK ILVPNSTAGM IIGKGGAFIK QIKEESGSYV QISQKPTDVS LQERCITIIG
DKENNKNACK MILSKIVEDP QSGTCLNVSY ADVSGPVANF NPTGSPYATN QNAINSSTAS
LNSTLGTTIG GANSAASLLV NGTGINLSIN LGSPNPAPNL AVATQLLEHI KVAMRGSGYS
ETVTNEVVAA LSVLAKYGVL GMGVGVSHTN GAHSTLGNFL GVTTLDQQTA AAASAATASN
VFGAVGQVNL EQYAAAVASA AAASRPTQSQ LDAAAVQFDP FRHLGSATAP AATPVSLNNN
SFGLTATTGT ATTAQLGGLS KSPTPGDLSS KDSKNVEVPE VIIGAILGPS GRSLVEIQHV
SGANVQISKK GIFAPGTRNR IVTITGQPSA IAKAQYLIEQ KINEEETKRA RQIPLTTVVN
