ID   NOVE_STRNV              Reviewed;         217 AA.
AC   Q9L9G3;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Transcriptional regulator NovE;
DE   AltName: Full=Novobiocin biosynthesis protein E;
GN   Name=novE;
OS   Streptomyces niveus (Streptomyces spheroides).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=193462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 23965 / DSM 40292 / JCM 4252 / NBRC 12917 / NCIMB 11891 / NRRL
RC   2449;
RX   PubMed=10770754; DOI=10.1128/aac.44.5.1214-1222.2000;
RA   Steffensky M., Muhlenweg A., Wang Z.X., Li S.M., Heide L.;
RT   "Identification of the novobiocin biosynthetic gene cluster of Streptomyces
RT   spheroides NCIB 11891.";
RL   Antimicrob. Agents Chemother. 44:1214-1222(2000).
RN   [2]
RP   PRELIMINARY FUNCTION.
RX   PubMed=12736771; DOI=10.1007/s00203-003-0555-2;
RA   Eustaquio A.S., Luft T., Wang Z.X., Gust B., Chater K.F., Li S.M.,
RA   Heide L.;
RT   "Novobiocin biosynthesis: inactivation of the putative regulatory gene novE
RT   and heterologous expression of genes involved in aminocoumarin ring
RT   formation.";
RL   Arch. Microbiol. 180:25-32(2003).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 23965 / DSM 40292 / JCM 4252 / NBRC 12917 / NCIMB 11891 / NRRL
RC   2449;
RX   PubMed=18568336; DOI=10.1007/s00203-008-0396-0;
RA   Dangel V., Eustaquio A.S., Gust B., Heide L.;
RT   "novE and novG act as positive regulators of novobiocin biosynthesis.";
RL   Arch. Microbiol. 190:509-519(2008).
RN   [4]
RP   FUNCTION.
RC   STRAIN=ATCC 23965 / DSM 40292 / JCM 4252 / NBRC 12917 / NCIMB 11891 / NRRL
RC   2449;
RX   PubMed=19762445; DOI=10.1099/mic.0.032649-0;
RA   Dangel V., Harle J., Goerke C., Wolz C., Gust B., Pernodet J.L., Heide L.;
RT   "Transcriptional regulation of the novobiocin biosynthetic gene cluster.";
RL   Microbiology 155:4025-4035(2009).
CC   -!- FUNCTION: Transcription regulator that specifically regulates
CC       expression of genes involved in the novobiocin biosynthesis pathway.
CC       Probably acts as a positive regulator of transcription. Does not bind
CC       DNA. {ECO:0000269|PubMed:18568336, ECO:0000269|PubMed:19762445}.
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DR   EMBL; AF170880; AAF67498.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9L9G3; -.
DR   SMR; Q9L9G3; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Transcription; Transcription regulation.
FT   CHAIN           1..217
FT                   /note="Transcriptional regulator NovE"
FT                   /id="PRO_0000423989"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  24767 MW;  3BFAF877DBDE0AFC CRC64;
     MVASGRTASK GRGNGATPVR PTAGDATPVD SGQPSDTTYG GLEVSAERTR LRIPRDLSLE
     AWCRLGGRIL AVCDSSVWWI GDWLVFGQNQ YGDRYRRAMK ETKLDYQTLR NYAWVARKFE
     PSRRRDSLTF QHHMEVAALS EAEQDHWLDF AVRLNWSRNE LRKQIRASLS GEEDDLRCEV
     QLNLQLDELR LERWREAARG SNLTLTDWIL SVVDGAV