NOV_ARATH
ID NOV_ARATH Reviewed; 2729 AA.
AC F4JTS8; Q9SVN7; Q9SVN8;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Protein NO VEIN {ECO:0000303|PubMed:19880797};
DE AltName: Full=Protein EMBRYO DEFECTIVE 2597 {ECO:0000303|PubMed:15266054};
GN Name=NOV {ECO:0000303|PubMed:19880797};
GN Synonyms=EMB2597 {ECO:0000303|PubMed:15266054};
GN OrderedLocusNames=At4g13750 {ECO:0000312|Araport:AT4G13750};
GN ORFNames=F18A5.130 {ECO:0000312|EMBL:CAB36838.1},
GN F18A5.140 {ECO:0000312|EMBL:CAB36839.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION [LARGE SCALE ANALYSIS], AND DISRUPTION PHENOTYPE [LARGE SCALE
RP ANALYSIS].
RC STRAIN=cv. Columbia;
RX PubMed=15266054; DOI=10.1104/pp.104.045179;
RA Tzafrir I., Pena-Muralla R., Dickerman A., Berg M., Rogers R., Hutchens S.,
RA Sweeney T.C., McElver J., Aux G., Patton D., Meinke D.;
RT "Identification of genes required for embryo development in Arabidopsis.";
RL Plant Physiol. 135:1206-1220(2004).
RN [4]
RP FUNCTION, MUTAGENESIS OF PRO-855, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, AND GENE FAMILY.
RX PubMed=19880797; DOI=10.1105/tpc.109.068841;
RA Tsugeki R., Ditengou F.A., Sumi Y., Teale W., Palme K., Okada K.;
RT "NO VEIN mediates auxin-dependent specification and patterning in the
RT Arabidopsis embryo, shoot, and root.";
RL Plant Cell 21:3133-3151(2009).
RN [5]
RP FUNCTION, AND MUTAGENESIS OF PRO-855.
RX PubMed=20729639; DOI=10.4161/psb.5.10.12948;
RA Tsugeki R., Ditengou F.A., Palme K., Okada K.;
RT "NO VEIN facilitates auxin-mediated development in Arabidopsis.";
RL Plant Signal. Behav. 5:1249-1251(2010).
CC -!- FUNCTION: Essential protein required for cell fate determination during
CC embryogenesis (PubMed:15266054). Mediates auxin-dependent coordinated
CC cell-fate specification and patterning in embryos (e.g. cotyledon
CC outgrowth and separation), shoots and roots (e.g. leaf vascular
CC development, cellular patterning and stem cell maintenance in the
CC meristems) (PubMed:19880797, PubMed:20729639). Required for provascular
CC PIN1 expression and region-specific expression of PIN7 in leaf
CC primordia, cell type-specific expression of PIN3, PIN4, and PIN7 in the
CC root, and PIN2 polarity in the root cortex (PubMed:19880797,
CC PubMed:20729639). {ECO:0000269|PubMed:15266054,
CC ECO:0000269|PubMed:19880797, ECO:0000269|PubMed:20729639}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC ECO:0000269|PubMed:19880797}. Note=Accumulates in speckles within the
CC nucleus and the nucleolus. {ECO:0000269|PubMed:19880797}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in developing embryos, leaf
CC primordia, and shoot and root apical meristems.
CC {ECO:0000269|PubMed:19880797}.
CC -!- DEVELOPMENTAL STAGE: In shoots, expressed in developing leaf primordia
CC and, weakly, in the shoot apical meristem (SAM). First observed
CC throughout young leaf primordia, but, as leaf primordia develop,
CC restricted to the adaxial side of primordia and then toward the basal
CC side. In seeds, present in developing embryos and later in provascular
CC cells of cotyledons at the early stage of vascular differentiation. In
CC roots, accumulates in the root apical meristem (RAM) with weak
CC expression in the quiescent center and columella initials but not in
CC mature root tissues; also expressed during primordial development of
CC lateral roots. {ECO:0000269|PubMed:19880797}.
CC -!- DISRUPTION PHENOTYPE: Embryo-defective phenotype characterized by size
CC reduction and frequent fusion of cotyledons.
CC {ECO:0000269|PubMed:15266054, ECO:0000269|PubMed:19880797}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB36838.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g13740 and At4g13750.; Evidence={ECO:0000305};
CC Sequence=CAB36839.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g13740 and At4g13750.; Evidence={ECO:0000305};
CC Sequence=CAB78416.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g13740 and At4g13750.; Evidence={ECO:0000305};
CC Sequence=CAB78417.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g13740 and At4g13750.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Seed defective Arabidopsis mutants;
CC URL="http://seedgenes.org/MutantList";
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DR EMBL; AL035528; CAB36838.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL035528; CAB36839.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161537; CAB78416.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161537; CAB78417.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83321.1; -; Genomic_DNA.
DR PIR; T05243; T05243.
DR PIR; T05244; T05244.
DR RefSeq; NP_193111.2; NM_117449.4.
DR STRING; 3702.AT4G13750.1; -.
DR PaxDb; F4JTS8; -.
DR PRIDE; F4JTS8; -.
DR ProteomicsDB; 210111; -.
DR EnsemblPlants; AT4G13750.1; AT4G13750.1; AT4G13750.
DR GeneID; 827009; -.
DR Gramene; AT4G13750.1; AT4G13750.1; AT4G13750.
DR KEGG; ath:AT4G13750; -.
DR Araport; AT4G13750; -.
DR TAIR; locus:2119470; AT4G13750.
DR eggNOG; ENOG502QQIR; Eukaryota.
DR HOGENOM; CLU_229311_0_0_1; -.
DR InParanoid; F4JTS8; -.
DR OMA; NSFLCHW; -.
DR OrthoDB; 41529at2759; -.
DR PRO; PR:F4JTS8; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JTS8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0009926; P:auxin polar transport; IMP:TAIR.
DR GO; GO:0001708; P:cell fate specification; IMP:TAIR.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR024975; NOV_C.
DR Pfam; PF13020; DUF3883; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..2729
FT /note="Protein NO VEIN"
FT /id="PRO_0000446981"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2482..2515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 194..201
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 473..480
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 2492..2515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 855
FT /note="P->S: In nov-1; many auxin-dependent development
FT defects including narrow rosette leaves with few veins.
FT Abnormal presence of starch granules in roots columella
FT stem cells associated with an altered maintenance of
FT cortex/endodermis stem cells. Enhanced effect of 1-
FT naphthylphthalamic acid (NPA), an inhibitor of polar auxin
FT transport. Disturbed subcellular localizations of PIN1,
FT PIN2, PIN3, PIN4 and PIN7 in leaf primordia and root tips."
FT /evidence="ECO:0000269|PubMed:19880797,
FT ECO:0000269|PubMed:20729639"
SQ SEQUENCE 2729 AA; 306349 MW; 6A94A95C2D853AC6 CRC64;
MQGNHDGSWS LHPSTNNGSG RANGNININT VPGGGYLPQA NPVFPNFNQP IRYPIPQFPA
NFYRPNFPDF SLGNPNFQPH QNLNFLHQQI PHQYGSAANH FLQNHNQNSF SFPPQSIPNN
DISISQNHGA FENSSLKRRR QEEVVQVTDV VPKSNFASGE SANNSFSVSL PIPIATDDSG
VSRVHGEKSS GKPKRKVDVL RIDKAVNKTR KLFVAAGESV SSTRVSRAVL EELQADSWRS
LGVQMQDVPS LRQLMAIEGK INAFIHCFVG ARRIVTLHDL EVAICRNEFV DSFDDLELGP
LLQHPLVLLY FPSISSSTGP VKITSEEIIS FLDSYLHTYM TEDVKLDEFL NFVASQKSVT
SKEKLGVRIQ SLRMYVSFIL DAKRQEGETL KVLLTELHQK YHIPSSKKQQ RDKSLTVSER
ADSFALHHKD YCGKHIRFDS SSSDENDNVY EVRNLNSSDH INSCPYPSVA EEMKRLGGSN
KKRKGERRNH EKSDSSKLLR KSPSKLQGHA KQEIPKLADD SEAKKVFSVD EADFTLSEGD
LRLFISTWKD TCKELSISTF VEKMLSFYNL GGSEGRAQIK RAKAMSSFPF VGLLNVAVTS
LRRGMWDSIY DNFQMTSLSD TTNTGSGNQV GEINPIENSE LSKTQHVMPP THCNTVEEII
RRLSLYFEHD LSGAKHIGIF RKLQTCENLL AEQFQVQDFE SLGWGGFFAF LEKHMLLLPT
QLQRFLSREL QEEFPLEVHV NENLLTLLLS QASEFSSDKV LSRQTLARLV AEQFPSISFK
VVGRDSEENF SEIIGKKKSS SKCVLFSATL LGAENSLTSK YLEESLTVGN DTEARSTTLN
AVASKEVLDV LLRVPLLSDL NSWCHWDLRY APQFGPLMGC LNEINSTDLL CLVTRDGKII
RADPSATADS FLEAALQGSA YRTAAQLLSL ISLNGRTHLP FSLLKCYAKR AFEVFFYNYS
EEMELNDRNS LVQMHGPEKL STSFDKVIVV GEKAKVAKRD YAASKFLLDC LGYLPGEFRS
LVVDILLPGL RSVVKDAPTR VLSACEQTEQ RIMLHDAGLL LGIVEWISDY HKFCSSCSPN
SSIVENASSN LDSGAGFVQN ELEDPVQTKQ RCMIVSEKSC EYKEEPHESC HTFGGSGILC
DSVGEAFTQT APEFYDNRAS VIDSIRRDEF GLDLTSSGSE MSMLQKQHAR LGRALQCLSQ
ELYSQDSHFI LELVQNADDN KYPEHVEPTL TFILQKTGIV VLNNECGFMP ENIRALCDVG
QSTKKGSGGY IGKKGIGFKS VFRVSDAPEI HSNGFHFKFD ISEGQIGYIL PTVVPPHDIE
SLSSMLSGRA LHLKDAGWNT CITLPFRAID SERTTVNHIE PMFSDLHPSL LLFLHRLQCI
VYRNVLDDSL LVMRKEVVSK NIVKVSCGEN SMTWFVASEK LKATNLRDDV QTTEISIGFT
LDMLEDGTYR SCMIQEPVFA FLPLRTYGLK FIIQGDFILT SSREDVDEDS PWNQWLLSEF
PGLFVDALRS FCSLPSFTQN LGKGVSSYMQ LVPLVGEVHG FFSSLPRSII SRLRTTNCLL
LEGDGEEWVP PCKVLRNWNE KIRVLLKDGL LQEHLALGFL DKDIVLSDSL SRALGIEDYG
PKTLVQILSS LSHKNGCLQS MGFTWLSSIL TELYLLFRSS GHGNVELGID KSLIDDLHKI
PFIPLSNGKF TSLDEGAVWL HHDTTGLDLG DVFEAFPVLY GNLRTIDHSL LLASSVDEKS
SVDDLVNMLC AIGVQKLSAH EIVKAHILPA FEARSTGAVD GLMVDYLCFV MTHLRSGCHI
CLKERKYIIS ELRSKALVLS NYGLKQLGEG SIHFGEEYGN QVNMKKLTKN LDISWHVVDG
TYLKHPASKF YACGLKEWRE FFQEIGIADF VQVVQVEKSI AEFYSVSHCE KYDINLLSPD
LTVKDWESPE LVDLLSLLHK SNGRKGCKYL LEVLDRLWDD CYYDKTTVNY NSGTHGIIRS
SESSFMRVIC DSLWIVSSMD SKLHLSKDLY HDCDDVQSIL GMNAPYAVPT VTSVKLLSDI
GFKTKVSLDD ALEVLESWVH CGDSFKSSIS QITRFYKYLW NEMADSKQKI TEKLHTLPSV
FVPHGIASRQ NDMISGIFLS LDDVYWNDSA GVLDEIKEIS SQISSVVEPL RRKTLGNIYP
GLHDFFVNGC GVPETPSFQE YLKILGQFAH NVSPSSAAKA VFKIFLKWSD DLNSGKSSED
VIHFKERLSE LEYTVLPTEN DKWVSLHSSF GLVCWCDNEK LKKRFKNKDK IEFISFGEND
DEGQEVLQTK VSGLMHSLGI PSISEVVKRE AKYEGLQDNT VTVSLVNWAL PYAQRYIFTL
HHEKYTQTKK TVHSQVKRLQ VFVVDKLSYR NVIPQYGISS KKEFKCSSLL QDKALYTTPS
LDSHSLFMEL SRLFFNGVPD LHLANFLHLI KTMAESGLSE EQMESFILNS QKVHQVPDGE
EIWSLKSAVK AKKKAGISLS WLPSSSKTRH GSSKTNTDDS KQELDTSSSK EDVTEALEEK
IPIEMTNTNL VSGYDNCAGT SSRASEPNPL HSMHMISGST SGNQAAMHLN PNLPHEWNNS
FTANFSDRDQ LHTGTPWAAQ AQQTGRKGEE IAYRYFVAKY GNEALVKWVN DQSETGLPYD
LMIENRGGKK EYVEVKATVS TRKDYFNLTV REWQFANEKG ESYIIAHVLL GNSNAILTQH
RNPVKLCQEG HLRLLVLMPN QRNEVNVTF
