ID   NP03_HHV11              Reviewed;         235 AA.
AC   P10187; Q76WT5;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Nuclear phosphoprotein UL3;
GN   ORFNames=UL3;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2846760; DOI=10.1099/0022-1317-69-11-2831;
RA   Perry L.J., McGeoch D.J.;
RT   "The DNA sequences of the long repeat region and adjoining parts of the
RT   long unique region in the genome of herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:2831-2846(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Patton;
RX   PubMed=16574492; DOI=10.1016/j.ymthe.2006.02.006;
RA   Dambach M.J., Trecki J., Martin N., Markovitz N.S.;
RT   "Oncolytic viruses derived from the gamma34.5-deleted herpes simplex virus
RT   recombinant R3616 encode a truncated UL3 protein.";
RL   Mol. Ther. 13:891-898(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL3 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; X14112; CAA32339.1; -; Genomic_DNA.
DR   EMBL; D00373; BAA00275.1; -; Genomic_DNA.
DR   EMBL; DQ073426; AAZ22830.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62225.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63465.1; -; Genomic_DNA.
DR   PIR; C28133; WMBEX3.
DR   PRIDE; P10187; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005035; Herpes_UL3.
DR   Pfam; PF03369; Herpes_UL3; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..235
FT                   /note="Nuclear phosphoprotein UL3"
FT                   /id="PRO_0000115892"
FT   REGION          38..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   235 AA;  25609 MW;  FDA96829D742912D CRC64;
     MVKPLVSYGS VMSGVGGEGV PSALAILASW GWTFDTPNHE SGISPDTTPA DSIRGAAVAS
     PDQPLHGGPE REATAPSFSP TRADDGPPCT DGPYVTFDTL FMVSSIDELG RRQLTDTIRK
     DLRLSLAKFS IACTKTSSFS GNAPRHHRRG AFQRGTRAPR SNKSLQMFVL CKRAHAARVR
     EQLRVVIQSR KPRKYYTRSS DGRLCPAVPV FVHEFVSSEP MRLHRDNVML ASGAE