ID   NP03_HHV1F              Reviewed;         235 AA.
AC   Q1XBW5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   02-JUN-2021, entry version 20.
DE   RecName: Full=Nuclear phosphoprotein UL3;
GN   ORFNames=UL3;
OS   Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10304;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX   PubMed=16574492; DOI=10.1016/j.ymthe.2006.02.006;
RA   Dambach M.J., Trecki J., Martin N., Markovitz N.S.;
RT   "Oncolytic viruses derived from the gamma34.5-deleted herpes simplex virus
RT   recombinant R3616 encode a truncated UL3 protein.";
RL   Mol. Ther. 13:891-898(2006).
RN   [2]
RP   PHOSPHORYLATION, AND ALTERNATIVE INITIATION.
RX   PubMed=10482549; DOI=10.1128/jvi.73.10.8010-8018.1999;
RA   Markovitz N.S., Filatov F., Roizman B.;
RT   "The U(L)3 protein of herpes simplex virus 1 is translated predominantly
RT   from the second in-frame methionine codon and is subject to at least two
RT   posttranslational modifications.";
RL   J. Virol. 73:8010-8018(1999).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q1XBW5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q1XBW5-2; Sequence=VSP_038182;
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- MISCELLANEOUS: [Isoform 1]: Minor isoform.
CC   -!- MISCELLANEOUS: [Isoform 2]: Major isoform. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL3 family.
CC       {ECO:0000305}.
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DR   EMBL; AY730706; AAW62372.1; -; Genomic_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005035; Herpes_UL3.
DR   Pfam; PF03369; Herpes_UL3; 1.
PE   1: Evidence at protein level;
KW   Alternative initiation; Host nucleus; Phosphoprotein.
FT   CHAIN           1..235
FT                   /note="Nuclear phosphoprotein UL3"
FT                   /id="PRO_0000385486"
FT   REGION          38..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..11
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_038182"
SQ   SEQUENCE   235 AA;  25639 MW;  E1C51829D757842D CRC64;
     MVKPLVSYGS VMSGVGGEGV PSALAILASW GWTFDTPNHE SGISPDTTPA DSIRGAAVAS
     PDQPLHGGPE REATAPSFSP TRADDGPPCT DGPYVTFDTL FMVSSIDELG RRQLTDTIRK
     DLRLSLAKFS IACTKTSSFS GNAPRHHRRG AFQRGTRAPR SNKSLQMFVL CKRTHAARVR
     EQLRVVIQSR KPRKYYTRSS DGRLCPAVPV FVHEFVSSEP MRLHRDNVML ASGAE