ID   NP03_HHV23              Reviewed;         233 AA.
AC   P0C012; O12511; Q89644;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=Nuclear phosphoprotein UL3;
GN   Name=UL3;
OS   Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10313;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
RX   PubMed=8337818; DOI=10.1006/viro.1993.1386;
RA   Worrad D.M., Caradonna S.J.;
RT   "The herpes simplex virus type 2 UL3 open reading frame encodes a nuclear
RT   localizing phosphoprotein.";
RL   Virology 195:364-376(1993).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:8337818}.
CC       Note=Has a perinuclear location early in infection and at later times
CC       becomes associated with the nucleus as discrete particles.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:8337818}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL3 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; M38699; AAA45860.1; -; mRNA.
DR   EMBL; L02638; AAC37787.1; -; mRNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005035; Herpes_UL3.
DR   Pfam; PF03369; Herpes_UL3; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Phosphoprotein.
FT   CHAIN           1..233
FT                   /note="Nuclear phosphoprotein UL3"
FT                   /id="PRO_0000115893"
FT   REGION          38..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   233 AA;  25534 MW;  314982C654BC3554 CRC64;
     MVKSRVSYRS VMSGVGEERV PSAFTILASW GWTFAPQNHD PGASPNTTPI ESIAGTAPDA
     HVGPLDGEPD RDAISPLTSS VAGDPPGADG PYVTFDTLFM VSSIDELGRR QLTDTIRKDL
     RLSLAKFSIA CTKTSSFSGT AARQRKRGAP PQRTCVPRSN KSLQMFVLCK RANAAQVREQ
     LRAVIRSRKP RKYYTRSSDG RLCPAVPVFV HEFVSSEPMR LHRDNVMLST EPD