ID   NP04_HHV11              Reviewed;         199 AA.
AC   P10188; Q09IC9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 65.
DE   RecName: Full=Nuclear protein UL4;
GN   ORFNames=UL4;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
RX   PubMed=2826807; DOI=10.1128/jvi.62.2.444-453.1988;
RA   McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P.,
RA   Challberg M.D.;
RT   "Structures of herpes simplex virus type 1 genes required for replication
RT   of virus DNA.";
RL   J. Virol. 62:444-453(1988).
RN   [4]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RC   STRAIN=17 syn+;
RX   PubMed=9880019; DOI=10.1099/0022-1317-79-12-3033;
RA   Eide T., Marsden H.S., Leib D.A., Cunningham C., Davison A.J.,
RA   Langeland N., Haarr L.;
RT   "Identification of the UL4 protein of herpes simplex virus type 1.";
RL   J. Gen. Virol. 79:3033-3038(1998).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:9880019}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL4 family.
CC       {ECO:0000305}.
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DR   EMBL; X14112; CAA32340.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63466.1; -; Genomic_DNA.
DR   EMBL; M19119; AAA45820.1; -; Genomic_DNA.
DR   PIR; D28133; WMBEX4.
DR   RefSeq; YP_009137078.1; NC_001806.2.
DR   IntAct; P10188; 1.
DR   MINT; P10188; -.
DR   PRIDE; P10188; -.
DR   DNASU; 2703362; -.
DR   GeneID; 2703362; -.
DR   KEGG; vg:2703362; -.
DR   Proteomes; UP000009294; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004958; Herpes_UL4.
DR   Pfam; PF03277; Herpes_UL4; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Nuclear protein UL4"
FT                   /id="PRO_0000115898"
FT   VARIANT         107
FT                   /note="S -> I (in strain: Nonneuroinvasive mutant HF10)"
SQ   SEQUENCE   199 AA;  21517 MW;  A50C0AB9FB9AA3F0 CRC64;
     MSNPQTTIAY SLCHARASLT SALPDAAQVV HVFEYGTRAI MVRGRERQDR LPRGGVVIQH
     TPIGLLVIID CRAEFCAYRF IGRDSNQKLE RGWDAHMYAY PFDSWVSSSR GESARSATAG
     ILTVVWTADT IYITATIYGS PPEETPGAAH GVGAAPPPPT TACPGTAEFL QPTADLLVEV
     LREIQLSPAL EYADKLLGS