ID   NP106_SCHPO             Reviewed;         933 AA.
AC   O14310;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Nucleoporin npp106;
DE   AltName: Full=Nuclear pore protein npp106;
GN   Name=npp106; ORFNames=SPCC1739.14;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9372936; DOI=10.1128/mcb.17.12.7047;
RA   Yoon J.H., Whalen W.A., Bharathi A., Shen R., Dhar R.;
RT   "Npp106p, a Schizosaccharomyces pombe homologue of Saccharomyces cerevisiae
RT   Nic96p, functionally interacts with Rae1p in mRNA export.";
RL   Mol. Cell. Biol. 17:7047-7060(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217; SER-219; THR-221 AND
RP   SER-237, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Has a role in promoting mRNA export from the nucleus.
CC       {ECO:0000269|PubMed:9372936}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:9372936}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000269|PubMed:9372936}.
CC   -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC       family. {ECO:0000305}.
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DR   EMBL; AF000150; AAB62188.1; -; Genomic_DNA.
DR   EMBL; CU329672; CAA20788.1; -; Genomic_DNA.
DR   PIR; T41122; T41122.
DR   RefSeq; NP_588422.1; NM_001023413.2.
DR   AlphaFoldDB; O14310; -.
DR   SMR; O14310; -.
DR   BioGRID; 275649; 5.
DR   STRING; 4896.SPCC1739.14.1; -.
DR   iPTMnet; O14310; -.
DR   MaxQB; O14310; -.
DR   PaxDb; O14310; -.
DR   PRIDE; O14310; -.
DR   EnsemblFungi; SPCC1739.14.1; SPCC1739.14.1:pep; SPCC1739.14.
DR   GeneID; 2539077; -.
DR   KEGG; spo:SPCC1739.14; -.
DR   PomBase; SPCC1739.14; npp106.
DR   VEuPathDB; FungiDB:SPCC1739.14; -.
DR   eggNOG; KOG2168; Eukaryota.
DR   HOGENOM; CLU_011846_0_0_1; -.
DR   InParanoid; O14310; -.
DR   OMA; LLMCGQF; -.
DR   PhylomeDB; O14310; -.
DR   PRO; PR:O14310; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IGI:PomBase.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0120290; P:stalled replication fork localization to nuclear periphery; IDA:PomBase.
DR   InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR   PANTHER; PTHR11225; PTHR11225; 1.
DR   Pfam; PF04097; Nic96; 1.
PE   1: Evidence at protein level;
KW   mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..933
FT                   /note="Nucleoporin npp106"
FT                   /id="PRO_0000124786"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         217
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         219
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         221
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         237
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   933 AA;  105714 MW;  8B24A88872666F5C CRC64;
     MESKEAKEKG VNTSDSKGSQ IESSISDLRE KSQHLFGVLL EPQVPVIQYG LNQLEEKARN
     LESKVLLTRD GDTKAHYLLA ESGMNAEQTR QKIYSIHIHS PWDQLELDKK SLYEQPHTKL
     YNGQNVVASI ENGYQSNVYE FQLRLMKNNG IAWENTKTEF MEDVGKLLHS KDNSGLGTSI
     SMSLRPNLAR PLLTASSVKS QSVRSLREVG SNLPIPTGSL TKIDGLNNQL SNDLTRSQTT
     NIFGFAEKAS SFAAAVHKLN EARIRNQACH VWSLFASVSQ MVNTEVIQLF DAWSLLAHMI
     DETRYGMGDF EARHLALDSS SAALAVEKNC IEGSLKYLEN QFLSLIDLHL SDAGHITTVN
     SVEKVIAYSK LRFYKNGSWI KSTVSVVNDV PLWVVLFYLM RSGQLDAALQ FVNTYSDDFE
     KLGRSFPLYF YSYAKNPSLP LPKQLRDRLQ AEYGQLMKYA PEDPFKHAIY KLLGNCEPHR
     VSLPEVCVTS EDYMWIQLMF CRVNQNDVID SNGGQSTNSL FNLYQLEKKI VAFGPRYFNP
     KNNTPTNYFL ALLMCGEFER AISFLHTNYP VEATHFAVAM AYYGLLRTKN YEKNENILIY
     EADDVKINFP QLIIAYLKHL EYVDAAVYLD YIACIPLVPA YQACSINLTK ILLLQSHEFS
     KFLGDIKPDT ERTTGLLDLY LRLIPFDHDS LQKLYLEGAR EADDDGRFGD SIILYHLLGD
     YDTVIGVAIK NLSQSIVSRG LWSIDSKESK NMHISSNVVA SEAPDALAAN LLAMYESNPK
     KSAKVSATNK KALKVLLKVV KVQKLYGQEK WDEVLQLIEH LDLLPINEVQ AEFEPNEQIP
     PISARLRRRA FEFSTFQDEV LSVIPSLMYI SMSSIKALYR TISKLPVVNE ESKKKLQRLQ
     FKGSMLVMFS TMIESRLSPQ ILEYLQAEQL TLL