ID   NP10_HUMAN              Reviewed;          75 AA.
AC   P61580;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Endogenous retrovirus group K member 10 Np9 protein;
DE   AltName: Full=HERV-K10 Np9 protein;
DE   AltName: Full=HERV-K107 Np9 protein;
DE   AltName: Full=HERV-K_5q33.3 provirus Np9 protein;
GN   Name=ERVK-10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3021993; DOI=10.1128/jvi.60.2.589-598.1986;
RA   Ono M., Yasunaga T., Miyata T., Ushikubo H.;
RT   "Nucleotide sequence of human endogenous retrovirus genome related to the
RT   mouse mammary tumor virus genome.";
RL   J. Virol. 60:589-598(1986).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=12060620;
RA   Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A.,
RA   Best B., Roemer K., Mueller-Lantzsch N.;
RT   "A novel gene from the human endogenous retrovirus K expressed in
RT   transformed cells.";
RL   Clin. Cancer Res. 8:1800-1807(2002).
CC   -!- FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.
CC   -!- MISCELLANEOUS: This Np9 protein is encoded by a human specific
CC       provirus.
CC   -!- MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains
CC       type 1 and type 2 genomes depending on the absence or presence of 292
CC       nucleotides at the 5'-end of the env gene. Np9 proteins are translated
CC       from a doubly spliced transcript expressed exclusively by HERV-K(HML-2)
CC       type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids
CC       with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is
CC       encoded by a small exon located at the 3' end of the envelope gene.
CC       This exon shares the same splice acceptor site and therefore overlaps
CC       HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from
CC       an alternate reading frame.
CC   -!- MISCELLANEOUS: Intragenic, in the sixth intron of the SCGD gene.
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DR   EMBL; M14123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P61580; -.
DR   STRING; 9606.ENSP00000485075; -.
DR   BioMuta; HGNC:39004; -.
DR   MassIVE; P61580; -.
DR   PRIDE; P61580; -.
DR   GeneCards; ERVK-10; -.
DR   HGNC; HGNC:39004; ERVK-10.
DR   neXtProt; NX_P61580; -.
DR   eggNOG; ENOG502TK7B; Eukaryota.
DR   PhylomeDB; P61580; -.
DR   Pharos; P61580; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   ERV; Nucleus; Reference proteome; Transposable element.
FT   CHAIN           1..75
FT                   /note="Endogenous retrovirus group K member 10 Np9 protein"
FT                   /id="PRO_0000186784"
FT   REGION          21..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   75 AA;  8892 MW;  43D00FBE4CA07136 CRC64;
     MNPSEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSNCYCV
     CVERSRHRRL HFVMC