NP1L2_HUMAN
ID NP1L2_HUMAN Reviewed; 460 AA.
AC Q9ULW6; B2RE61; B4E161; Q8TAN6;
DT 13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Nucleosome assembly protein 1-like 2;
DE AltName: Full=Brain-specific protein, X-linked;
GN Name=NAP1L2; Synonyms=BPX;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N.,
RA Saito T.;
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Li N.G., Yu L., Zhao S.Y.;
RT "Cloning of a new human cDNA homologous to Mus musculus Bpx protein.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acidic protein which may be involved in interactions with
CC other proteins or DNA. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9ULW6; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-3911716, EBI-10749669;
CC Q9ULW6; Q8N715: CCDC185; NbExp=3; IntAct=EBI-3911716, EBI-740814;
CC Q9ULW6; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-3911716, EBI-399105;
CC Q9ULW6; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-3911716, EBI-11993062;
CC Q9ULW6; P42858: HTT; NbExp=3; IntAct=EBI-3911716, EBI-466029;
CC Q9ULW6; O95198: KLHL2; NbExp=3; IntAct=EBI-3911716, EBI-746999;
CC Q9ULW6; Q96HR3: MED30; NbExp=3; IntAct=EBI-3911716, EBI-394659;
CC Q9ULW6; P55209: NAP1L1; NbExp=3; IntAct=EBI-3911716, EBI-356392;
CC Q9ULW6; Q99457: NAP1L3; NbExp=3; IntAct=EBI-3911716, EBI-8645631;
CC Q9ULW6; Q96NT1: NAP1L5; NbExp=5; IntAct=EBI-3911716, EBI-713627;
CC Q9ULW6; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-3911716, EBI-1105153;
CC Q9ULW6; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-3911716, EBI-748391;
CC Q9ULW6; O60239: SH3BP5; NbExp=3; IntAct=EBI-3911716, EBI-624860;
CC Q9ULW6; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-3911716, EBI-11952721;
CC Q9ULW6; PRO_0000037551 [Q9WMX2]; Xeno; NbExp=2; IntAct=EBI-3911716, EBI-6863748;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ULW6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ULW6-2; Sequence=VSP_057064;
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB027013; BAA84706.1; -; mRNA.
DR EMBL; AF136178; AAP97268.1; -; mRNA.
DR EMBL; CR457095; CAG33376.1; -; mRNA.
DR EMBL; AK303676; BAG64673.1; -; mRNA.
DR EMBL; AK316569; BAG38158.1; -; mRNA.
DR EMBL; AC004074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471104; EAW98670.1; -; Genomic_DNA.
DR EMBL; BC026325; AAH26325.1; -; mRNA.
DR CCDS; CCDS14423.1; -. [Q9ULW6-1]
DR RefSeq; NP_068798.1; NM_021963.3. [Q9ULW6-1]
DR AlphaFoldDB; Q9ULW6; -.
DR SMR; Q9ULW6; -.
DR BioGRID; 110755; 37.
DR IntAct; Q9ULW6; 20.
DR STRING; 9606.ENSP00000362616; -.
DR iPTMnet; Q9ULW6; -.
DR PhosphoSitePlus; Q9ULW6; -.
DR BioMuta; NAP1L2; -.
DR DMDM; 22256943; -.
DR EPD; Q9ULW6; -.
DR jPOST; Q9ULW6; -.
DR MassIVE; Q9ULW6; -.
DR PaxDb; Q9ULW6; -.
DR PeptideAtlas; Q9ULW6; -.
DR PRIDE; Q9ULW6; -.
DR ProteomicsDB; 5729; -.
DR ProteomicsDB; 85143; -. [Q9ULW6-1]
DR Antibodypedia; 27991; 138 antibodies from 20 providers.
DR DNASU; 4674; -.
DR Ensembl; ENST00000373517.4; ENSP00000362616.3; ENSG00000186462.9. [Q9ULW6-1]
DR GeneID; 4674; -.
DR KEGG; hsa:4674; -.
DR MANE-Select; ENST00000373517.4; ENSP00000362616.3; NM_021963.4; NP_068798.1.
DR UCSC; uc004ebi.4; human. [Q9ULW6-1]
DR CTD; 4674; -.
DR DisGeNET; 4674; -.
DR GeneCards; NAP1L2; -.
DR HGNC; HGNC:7638; NAP1L2.
DR HPA; ENSG00000186462; Tissue enhanced (brain).
DR MIM; 300026; gene.
DR neXtProt; NX_Q9ULW6; -.
DR OpenTargets; ENSG00000186462; -.
DR PharmGKB; PA31440; -.
DR VEuPathDB; HostDB:ENSG00000186462; -.
DR eggNOG; KOG1507; Eukaryota.
DR GeneTree; ENSGT00940000163372; -.
DR HOGENOM; CLU_038841_3_1_1; -.
DR InParanoid; Q9ULW6; -.
DR OMA; WMAAIEE; -.
DR OrthoDB; 1216172at2759; -.
DR PhylomeDB; Q9ULW6; -.
DR TreeFam; TF314349; -.
DR PathwayCommons; Q9ULW6; -.
DR SignaLink; Q9ULW6; -.
DR BioGRID-ORCS; 4674; 8 hits in 697 CRISPR screens.
DR GenomeRNAi; 4674; -.
DR Pharos; Q9ULW6; Tbio.
DR PRO; PR:Q9ULW6; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9ULW6; protein.
DR Bgee; ENSG00000186462; Expressed in endothelial cell and 167 other tissues.
DR Genevisible; Q9ULW6; HS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0044154; P:histone H3-K14 acetylation; IEA:Ensembl.
DR GO; GO:0043970; P:histone H3-K9 acetylation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IEA:Ensembl.
DR GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:2000035; P:regulation of stem cell division; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..460
FT /note="Nucleosome assembly protein 1-like 2"
FT /id="PRO_0000185655"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 346..352
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 28..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..142
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057064"
FT CONFLICT 3
FT /note="E -> K (in Ref. 7; AAH26325)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 52542 MW; 36BE77964B5096C6 CRC64;
MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE
NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT
RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM
CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI
PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE
LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT
VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV
VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR
