NP1L3_MOUSE
ID NP1L3_MOUSE Reviewed; 544 AA.
AC Q794H2; B1AZU8; O54802;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Nucleosome assembly protein 1-like 3;
DE AltName: Full=Brain-specific protein MB20;
GN Name=Nap1l3; Synonyms=Mb20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11161794; DOI=10.1006/geno.2000.6397;
RA Shen H.H., Huang A.M., Hoheisel J., Tsai S.F.;
RT "Identification and characterization of a SET/NAP protein encoded by a
RT brain-specific gene, MB20.";
RL Genomics 71:21-33(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11161794}. Cytoplasm
CC {ECO:0000269|PubMed:11161794}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:11161794}.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
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DR EMBL; AB010711; BAA24570.1; -; mRNA.
DR EMBL; BX005467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020176; AAH20176.1; -; mRNA.
DR EMBL; BC027045; AAH27045.1; -; mRNA.
DR CCDS; CCDS30372.1; -.
DR RefSeq; NP_620081.1; NM_138742.1.
DR AlphaFoldDB; Q794H2; -.
DR SMR; Q794H2; -.
DR BioGRID; 207676; 2.
DR STRING; 10090.ENSMUSP00000078453; -.
DR iPTMnet; Q794H2; -.
DR PhosphoSitePlus; Q794H2; -.
DR PaxDb; Q794H2; -.
DR PRIDE; Q794H2; -.
DR ProteomicsDB; 252999; -.
DR Antibodypedia; 14445; 134 antibodies from 19 providers.
DR DNASU; 54561; -.
DR Ensembl; ENSMUST00000079490; ENSMUSP00000078453; ENSMUSG00000055733.
DR GeneID; 54561; -.
DR KEGG; mmu:54561; -.
DR UCSC; uc009uel.1; mouse.
DR CTD; 4675; -.
DR MGI; MGI:1859565; Nap1l3.
DR VEuPathDB; HostDB:ENSMUSG00000055733; -.
DR eggNOG; KOG1507; Eukaryota.
DR GeneTree; ENSGT00940000162927; -.
DR HOGENOM; CLU_038841_0_0_1; -.
DR InParanoid; Q794H2; -.
DR OMA; GKDYGNR; -.
DR OrthoDB; 1216172at2759; -.
DR PhylomeDB; Q794H2; -.
DR TreeFam; TF314349; -.
DR BioGRID-ORCS; 54561; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q794H2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q794H2; protein.
DR Bgee; ENSMUSG00000055733; Expressed in dorsomedial nucleus of hypothalamus and 194 other tissues.
DR Genevisible; Q794H2; MM.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..544
FT /note="Nucleosome assembly protein 1-like 3"
FT /id="PRO_0000236211"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..209
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61377 MW; 021CCD79C124F92B CRC64;
MAEADPKMVT EPGAHGVAEE AMASTACDSG DESDSNSSSS TNSCSSSGSS SSGSSSSSSS
SSSSSSSSSS SSSGSSGSSS NGSHLNRKKR VPEPSRRAQR RPSGKLFLDK LPQAVRNRVQ
ALRNIQNECD KVDTLFLRAI HDLERKYAEL NKPLYDKRFQ IINAEYEPTE EECEWNSEEE
FSGDEEMQDD TPNEMPPLEG EEEEESCNEK AEVKEEGTHV PEEVPEAKVE EEEAPKETPE
VKTEEKDIPK EGAEEKAEEQ ESSKEIPEVK GEEKADSTDC IDIAPEEKED VKEVTQANTE
NKDQPTEEFT PRAPAREAQK RVPETRPEEG VNIKRARKGK PKKEDPKGIP DYWLTVLKNV
DKLGPMIQKC DEPILKFLSD VSLKFSNPGQ PIGYTFEFHF LPNPYFRNEL LMKTYIIRSK
PDHYDPFFAW GWEIEECKGC KIDWRRGKDV TVTTTRSRPG ITGEIEVQPR VVPNASFFNF
FSPPEIPLIG KLEPREDAIL DEDFEIGQIL HDNVILKSIY YFTGEINDPY YHDFRDYGNR
KYYK
