NP1L5_HUMAN
ID NP1L5_HUMAN Reviewed; 182 AA.
AC Q96NT1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Nucleosome assembly protein 1-like 5;
DE AltName: Full=Down-regulated in liver malignancy;
GN Name=NAP1L5; Synonyms=DRLM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12383514; DOI=10.1016/s0378-1119(02)00855-7;
RA Harada H., Nagai H., Ezura Y., Yokota T., Ohsawa I., Yamaguchi K., Ohue C.,
RA Tsuneizumi M., Mikami I., Terada Y., Yabe A., Emi M.;
RT "Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22
RT that encodes a NAP-like protein.";
RL Gene 296:171-177(2002).
CC -!- INTERACTION:
CC Q96NT1; P18848: ATF4; NbExp=3; IntAct=EBI-713627, EBI-492498;
CC Q96NT1; Q9ULW6: NAP1L2; NbExp=5; IntAct=EBI-713627, EBI-3911716;
CC Q96NT1; P08579: SNRPB2; NbExp=3; IntAct=EBI-713627, EBI-1053651;
CC Q96NT1; Q6PIF2: SYCE2; NbExp=5; IntAct=EBI-713627, EBI-11958386;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in brain.
CC {ECO:0000269|PubMed:12383514}.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
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DR EMBL; AK054689; BAB70793.1; -; mRNA.
DR EMBL; CH471057; EAX06025.1; -; Genomic_DNA.
DR EMBL; BC104883; AAI04884.1; -; mRNA.
DR CCDS; CCDS3632.1; -.
DR RefSeq; NP_715638.1; NM_153757.3.
DR AlphaFoldDB; Q96NT1; -.
DR SMR; Q96NT1; -.
DR BioGRID; 129344; 74.
DR IntAct; Q96NT1; 31.
DR MINT; Q96NT1; -.
DR STRING; 9606.ENSP00000320488; -.
DR iPTMnet; Q96NT1; -.
DR PhosphoSitePlus; Q96NT1; -.
DR BioMuta; NAP1L5; -.
DR DMDM; 74732635; -.
DR EPD; Q96NT1; -.
DR MassIVE; Q96NT1; -.
DR MaxQB; Q96NT1; -.
DR PaxDb; Q96NT1; -.
DR PeptideAtlas; Q96NT1; -.
DR PRIDE; Q96NT1; -.
DR ProteomicsDB; 77554; -.
DR Antibodypedia; 25656; 103 antibodies from 23 providers.
DR DNASU; 266812; -.
DR Ensembl; ENST00000323061.7; ENSP00000320488.5; ENSG00000177432.8.
DR GeneID; 266812; -.
DR KEGG; hsa:266812; -.
DR MANE-Select; ENST00000323061.7; ENSP00000320488.5; NM_153757.4; NP_715638.1.
DR UCSC; uc003hrx.4; human.
DR CTD; 266812; -.
DR DisGeNET; 266812; -.
DR GeneCards; NAP1L5; -.
DR HGNC; HGNC:19968; NAP1L5.
DR HPA; ENSG00000177432; Tissue enhanced (brain).
DR MIM; 612203; gene.
DR neXtProt; NX_Q96NT1; -.
DR OpenTargets; ENSG00000177432; -.
DR PharmGKB; PA134921404; -.
DR VEuPathDB; HostDB:ENSG00000177432; -.
DR eggNOG; KOG1507; Eukaryota.
DR GeneTree; ENSGT00730000111564; -.
DR HOGENOM; CLU_133891_0_0_1; -.
DR InParanoid; Q96NT1; -.
DR OMA; AGAKHDD; -.
DR OrthoDB; 1540924at2759; -.
DR PhylomeDB; Q96NT1; -.
DR PathwayCommons; Q96NT1; -.
DR SignaLink; Q96NT1; -.
DR BioGRID-ORCS; 266812; 13 hits in 1084 CRISPR screens.
DR ChiTaRS; NAP1L5; human.
DR GenomeRNAi; 266812; -.
DR Pharos; Q96NT1; Tbio.
DR PRO; PR:Q96NT1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96NT1; protein.
DR Bgee; ENSG00000177432; Expressed in endothelial cell and 188 other tissues.
DR Genevisible; Q96NT1; HS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..182
FT /note="Nucleosome assembly protein 1-like 5"
FT /id="PRO_0000317142"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..107
FT /evidence="ECO:0000255"
FT COMPBIAS 134..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 154
FT /note="E -> Q (in dbSNP:rs13109442)"
FT /id="VAR_050227"
SQ SEQUENCE 182 AA; 19593 MW; 8774791B37F99986 CRC64;
MADSENQGPA EPSQAAAAAE AAAEEVMAEG GAQGGDCDSA AGDPDSAAGQ MAEEPQTPAE
NAPKPKNDFI ESLPNSVKCR VLALKKLQKR CDKIEAKFDK EFQALEKKYN DIYKPLLAKI
QELTGEMEGC AWTLEGEEEE EEEYEDDEEE GEDEEEEEAA AEAAAGAKHD DAHAEMPDDA
KK
