ID   NP1_HBOC2               Reviewed;         214 AA.
AC   B9UYK6; C6KF53;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Non-structural protein NP-1;
DE            Short=NP1;
GN   Name=NP1; Synonyms=NP-1;
OS   Human bocavirus 2 (HBoV2) (Human bocavirus type 2).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Bocaparvovirus;
OC   Primate bocaparvovirus 2.
OX   NCBI_TaxID=573977;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PK-5510;
RX   PubMed=19072716; DOI=10.1086/595831;
RA   Kapoor A., Slikas E., Simmonds P., Chieochansin T., Naeem A., Shaukat S.,
RA   Alam M.M., Sharif S., Angez M., Zaidi S., Delwart E.;
RT   "A newly identified bocavirus species in human stool.";
RL   J. Infect. Dis. 199:196-200(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU1 {ECO:0000312|EMBL:ACS74734.1};
RX   PubMed=20457462; DOI=10.1016/j.virol.2010.04.014;
RA   Chen A.Y., Cheng F., Lou S., Luo Y., Liu Z., Delwart E., Pintel D., Qiu J.;
RT   "Characterization of the gene expression profile of human bocavirus.";
RL   Virology 403:145-154(2010).
CC   -!- FUNCTION: Required for the expression of the capsid proteins. Performs
CC       the splicing and internal polyadenylation of the viral capsid-encoding
CC       mRNA precursor, which allows its maturation and expression.
CC       Transactivates the viral promoter. {ECO:0000250|UniProtKB:Q3YPH5}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:Q3YPH5}.
CC   -!- SIMILARITY: Belongs to the Bocaparvovirus Non-structural protein NP-1
CC       family. {ECO:0000305}.
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DR   EMBL; FJ170278; ACJ38932.1; -; Genomic_DNA.
DR   EMBL; GQ200737; ACS74734.1; -; Genomic_DNA.
DR   RefSeq; YP_002586774.1; NC_012042.1.
DR   GeneID; 7755623; -.
DR   KEGG; vg:7755623; -.
DR   Proteomes; UP000098880; Genome.
DR   Proteomes; UP000150026; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0033120; P:positive regulation of RNA splicing; IMP:CACAO.
DR   GO; GO:0031564; P:transcription antitermination; IMP:CACAO.
DR   InterPro; IPR021075; Bocavirus_NP1.
DR   Pfam; PF11733; NP1-WLL; 1.
PE   3: Inferred from homology;
KW   Activator; Host nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..214
FT                   /note="Non-structural protein NP-1"
FT                   /id="PRO_0000445638"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  25327 MW;  82E214A269CBBD19 CRC64;
     MSSESMKNKH RNSKRTPSPL QKERRRNWES HKSRSRSPIR RHGEKNLEYA HHSNQENRQS
     SYTALKTSDQ ATKTKEKTSG GNRTNPYTVF SQHRANHSDA PGWCGFYWHS TRLARDGTNC
     IFNEMKQEFQ ELQINGKITW DNARELLFSQ KKKLDQKYRN MLYHFRHSPD CPRCDYWDNV
     YRRHLAHVSS QESEEVTDEE MLSAVESMDT NASN