ID   NP1_HBOC4               Reviewed;         214 AA.
AC   C5IY45;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   23-FEB-2022, entry version 27.
DE   RecName: Full=Non-structural protein NP-1;
DE            Short=NP1;
GN   Name=NP1; Synonyms=NP-1;
OS   Human bocavirus 4 (HBoV4) (Human bocavirus type 4).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Bocaparvovirus;
OC   Primate bocaparvovirus 2.
OX   NCBI_TaxID=1511883;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HBoV4-NI-385;
RX   PubMed=20415538; DOI=10.1086/652416;
RA   Kapoor A., Simmonds P., Slikas E., Li L., Bodhidatta L., Sethabutr O.,
RA   Triki H., Bahri O., Oderinde B.S., Baba M.M., Bukbuk D.N., Besser J.,
RA   Bartkus J., Delwart E.;
RT   "Human bocaviruses are highly diverse, dispersed, recombination prone, and
RT   prevalent in enteric infections.";
RL   J. Infect. Dis. 201:1633-1643(2010).
CC   -!- FUNCTION: Required for the expression of the capsid proteins. Performs
CC       the splicing and internal polyadenylation of the viral capsid-encoding
CC       mRNA precursor, which allows its maturation and expression.
CC       Transactivates the viral promoter. {ECO:0000250|UniProtKB:Q3YPH5}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:Q3YPH5}.
CC   -!- SIMILARITY: Belongs to the Bocaparvovirus Non-structural protein NP-1
CC       family. {ECO:0000305}.
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DR   EMBL; FJ973561; ACR15780.1; -; Genomic_DNA.
DR   RefSeq; YP_002916061.1; NC_012729.2.
DR   DNASU; 7922601; -.
DR   GeneID; 7922601; -.
DR   KEGG; vg:7922601; -.
DR   Proteomes; UP000106086; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021075; Bocavirus_NP1.
DR   Pfam; PF11733; NP1-WLL; 1.
PE   3: Inferred from homology;
KW   Activator; Host nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..214
FT                   /note="Non-structural protein NP-1"
FT                   /id="PRO_0000445640"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  25212 MW;  A35102AF98FF3A27 CRC64;
     MSSESTKNRH RSSKRTPSPL QKERKRNWEN RKSRSRSPIR RHGEKNLEYA HHNNQDNRQS
     SYTASKTSDQ AMKTKEKTSG GTRTNPYTVF SQHRANHSNA PGWCGFYWHS TRLARNGTNN
     IFNEMKQKFQ ELQIDGKISW DTTRELLFTQ KKTLDQGYRN MLYHFRHSPD CPRCDYWDDV
     YRKHLANVSS QESEEVTDEE MLSAVESMET NASN