ID   NP5_HUMAN               Reviewed;          75 AA.
AC   P61583;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Endogenous retrovirus group K member 5 Np9 protein;
DE   AltName: Full=Endogenous retrovirus K protein 5;
DE   AltName: Full=HERV-K(II) Np9 protein;
DE   AltName: Full=HERV-K_3q12.3 provirus Np9 protein;
GN   Name=ERVK-5; Synonyms=ERVK5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11401426; DOI=10.1006/geno.2001.6473;
RA   Sugimoto J., Matsuura N., Kinjo Y., Takasu N., Oda T., Jinno Y.;
RT   "Transcriptionally active HERV-K genes: identification, isolation, and
RT   chromosomal mapping.";
RL   Genomics 72:137-144(2001).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=12060620;
RA   Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A.,
RA   Best B., Roemer K., Mueller-Lantzsch N.;
RT   "A novel gene from the human endogenous retrovirus K expressed in
RT   transformed cells.";
RL   Clin. Cancer Res. 8:1800-1807(2002).
CC   -!- FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains
CC       type 1 and type 2 genomes depending on the absence or presence of 292
CC       nucleotides at the 5'-end of the env gene. Np9 proteins are translated
CC       from a doubly spliced transcript expressed exclusively by HERV-K(HML-2)
CC       type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids
CC       with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is
CC       encoded by a small exon located at the 3' end of the envelope gene.
CC       This exon shares the same splice acceptor site and therefore overlaps
CC       HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from
CC       an alternate reading frame.
CC   -!- MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and
CC       FLJ23047.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB047240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P61583; -.
DR   BioMuta; HGNC:13757; -.
DR   MassIVE; P61583; -.
DR   PRIDE; P61583; -.
DR   GeneCards; ERVK-5; -.
DR   HGNC; HGNC:13757; ERVK-5.
DR   MIM; 614012; gene.
DR   neXtProt; NX_P61583; -.
DR   PhylomeDB; P61583; -.
DR   Pharos; P61583; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   ERV; Nucleus; Reference proteome; Transposable element.
FT   CHAIN           1..75
FT                   /note="Endogenous retrovirus group K member 5 Np9 protein"
FT                   /id="PRO_0000186787"
FT   REGION          22..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   75 AA;  8907 MW;  56336D6321C07235 CRC64;
     MNPSEMQRKG PPQRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSDCYCV
     CVERSRHRRL HFVLY