NP7_HUMAN
ID NP7_HUMAN Reviewed; 75 AA.
AC P61582;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Endogenous retrovirus group K member 7 Np9 protein;
DE AltName: Full=HERV-K(III) Np9 protein;
DE AltName: Full=HERV-K102 Np9 protein;
DE AltName: Full=HERV-K_1q22 provirus Np9 protein;
GN Name=ERVK-7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10469592; DOI=10.1016/s0960-9822(99)80390-x;
RA Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.;
RT "Many human endogenous retrovirus K (HERV-K) proviruses are unique to
RT humans.";
RL Curr. Biol. 9:861-868(1999).
RN [2]
RP IDENTIFICATION.
RX PubMed=12060620;
RA Armbruester V., Sauter M., Krautkraemer E., Meese E.U., Kleiman A.,
RA Best B., Roemer K., Mueller-Lantzsch N.;
RT "A novel gene from the human endogenous retrovirus K expressed in
RT transformed cells.";
RL Clin. Cancer Res. 8:1800-1807(2002).
CC -!- FUNCTION: May possess a function in tumorigenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=When overexpressed.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Protein expressed at very low level. {ECO:0000250}.
CC -!- MISCELLANEOUS: This Np9 protein is encoded by a human specific
CC provirus.
CC -!- MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains
CC type 1 and type 2 genomes depending on the absence or presence of 292
CC nucleotides at the 5'-end of the env gene. Np9 proteins are translated
CC from a doubly spliced transcript expressed exclusively by HERV-K(HML-2)
CC type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids
CC with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is
CC encoded by a small exon located at the 3' end of the envelope gene.
CC This exon shares the same splice acceptor site and therefore overlaps
CC HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from
CC an alternate reading frame.
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DR EMBL; AF164610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P61582; -.
DR BioMuta; HGNC:31828; -.
DR PRIDE; P61582; -.
DR GeneCards; ERVK-7; -.
DR HGNC; HGNC:31828; ERVK-7.
DR MIM; 614013; gene.
DR neXtProt; NX_P61582; -.
DR PhylomeDB; P61582; -.
DR Pharos; P61582; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 3: Inferred from homology;
KW ERV; Nucleus; Reference proteome; Transposable element.
FT CHAIN 1..75
FT /note="Endogenous retrovirus group K member 7 Np9 protein"
FT /id="PRO_0000186786"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 75 AA; 8820 MW; D973170882C07138 CRC64;
MNPLEMQRKG PPRRWCLQVY PTAPKRQRPS RTGHDDDGGF VEKKRGKCGE KQERSDCYCV
CVERSRHGRL HFVMC