ID   NPAB_LOCMI              Reviewed;         107 AA.
AC   P10776;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 3.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Neuroparsin-A;
DE            Short=NPA;
DE   Contains:
DE     RecName: Full=Neuroparsin-B;
DE              Short=NPB;
DE   Flags: Precursor;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RA   Lagueux M., Kromer E., Girardie J.;
RT   "Cloning of a Locusta cDNA encoding neuroparsin A.";
RL   Insect Biochem. Mol. Biol. 22:511-516(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 25-107.
RA   Girardie J., Huet J.-C., Pernollet J.-C.;
RT   "The locust neuroparsin A: sequence and similarities with vertebrate and
RT   insect polypeptide hormones.";
RL   Insect Biochem. 20:659-666(1990).
RN   [3]
RP   PROTEIN SEQUENCE OF 30-107.
RC   TISSUE=Neuropora cardiaca;
RX   PubMed=2924926; DOI=10.1016/0014-5793(89)80179-6;
RA   Girardie J., Girardie A., Huet J.-C., Pernollet J.-C.;
RT   "Amino acid sequence of locust neuroparsins.";
RL   FEBS Lett. 245:4-8(1989).
CC   -!- FUNCTION: Neurosparins are multifunctional neurohormones: they inhibit
CC       the effects of juvenile hormone, stimulate fluid reabsorption of
CC       isolated recta and induces an increase in hemolymph lipid and trehalose
CC       levels.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
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DR   EMBL; Y17710; CAA76829.1; -; mRNA.
DR   PIR; A61618; A60361.
DR   AlphaFoldDB; P10776; -.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR010850; Neuroparsin.
DR   Pfam; PF07327; Neuroparsin; 1.
DR   PIRSF; PIRSF001836; Neuroparsin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide; Signal.
FT   SIGNAL          1..22
FT   PROPEP          23..24
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000021827"
FT   PEPTIDE         25..107
FT                   /note="Neuroparsin-A"
FT                   /id="PRO_0000021828"
FT   PEPTIDE         30..107
FT                   /note="Neuroparsin-B"
FT                   /id="PRO_0000021829"
SQ   SEQUENCE   107 AA;  11315 MW;  F97943370462D181 CRC64;
     MKATAALVAA TLLLAVTLFH RAERNPISRS CEGANCVVDL TRCEYGDVTD FFGRKVCAKG
     PGDKCGGPYE LHGKCGVGMD CRCGLCSGCS LHNLQCFFFE GGLPSSC