NPAL3_MOUSE
ID NPAL3_MOUSE Reviewed; 410 AA.
AC Q8BGN5; Q6PG85; Q9D2Y2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=NIPA-like protein 3;
GN Name=Nipal3; Synonyms=Npal3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Ovary, Spinal cord, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NIPA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31323.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC057168; AAH57168.1; -; mRNA.
DR EMBL; AK018640; BAB31323.1; ALT_SEQ; mRNA.
DR EMBL; AK049696; BAC33879.1; -; mRNA.
DR EMBL; AK087811; BAC40011.1; -; mRNA.
DR EMBL; AK138843; BAE23796.1; -; mRNA.
DR CCDS; CCDS18786.1; -.
DR RefSeq; NP_083271.1; NM_028995.3.
DR RefSeq; XP_017175906.1; XM_017320417.1.
DR AlphaFoldDB; Q8BGN5; -.
DR STRING; 10090.ENSMUSP00000099608; -.
DR PhosphoSitePlus; Q8BGN5; -.
DR MaxQB; Q8BGN5; -.
DR PaxDb; Q8BGN5; -.
DR PeptideAtlas; Q8BGN5; -.
DR PRIDE; Q8BGN5; -.
DR ProteomicsDB; 253002; -.
DR Antibodypedia; 30307; 100 antibodies from 14 providers.
DR Ensembl; ENSMUST00000102549; ENSMUSP00000099608; ENSMUSG00000028803.
DR GeneID; 74552; -.
DR KEGG; mmu:74552; -.
DR UCSC; uc008vgo.1; mouse.
DR CTD; 57185; -.
DR MGI; MGI:1921802; Nipal3.
DR VEuPathDB; HostDB:ENSMUSG00000028803; -.
DR eggNOG; KOG2922; Eukaryota.
DR GeneTree; ENSGT00940000158233; -.
DR HOGENOM; CLU_012349_2_0_1; -.
DR InParanoid; Q8BGN5; -.
DR OMA; TFYLDFM; -.
DR TreeFam; TF313214; -.
DR Reactome; R-MMU-5223345; Miscellaneous transport and binding events.
DR BioGRID-ORCS; 74552; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Nipal3; mouse.
DR PRO; PR:Q8BGN5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BGN5; protein.
DR Bgee; ENSMUSG00000028803; Expressed in otolith organ and 207 other tissues.
DR ExpressionAtlas; Q8BGN5; baseline and differential.
DR Genevisible; Q8BGN5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570; PTHR12570; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..410
FT /note="NIPA-like protein 3"
FT /id="PRO_0000242151"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 376
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P499"
FT CONFLICT 55
FT /note="L -> P (in Ref. 2; AAH57168)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="R -> G (in Ref. 1; BAB31323)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="V -> M (in Ref. 1; BAB31323)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 410 AA; 44808 MW; 830585F2DDEEF6FF CRC64;
MDGAHSAGLQ LQPLPPTSGA TSTSLSSSEG SFSYKENLIG ALLAIFGHLV VSIALNLQKY
CHIRLAGSKD PRAYFKTKTW WLGLLLLLLG ELGVFASYAF APLSLIVPLS AVSVIASAII
GIIFIKEKWK PKDFVRRYVL SFVGCGLAIV GTYLLVTFAP NSHEKMTGEN IARHLVSWPF
LLYMLVAIVL FCLLLYFYKE RNANSIVVIL LLVALLGSMT VVTVKAVSGM LVLSIQGNLQ
LDYPIFYVMF VCMVATAIYQ ATFLSEASQI YDSSLIASVG YILSTTAAIT AGAIFYLDFL
GEEALHICMF ALGCLIAFLG VFLITRNRKK AIPFEPYISM DAMPGMQDMH AKGTTVQPDL
KASFSYGALE SNDSISELYT PATLPVMQEE HSSRSTPGVP YRVLEHTKKE
