ID   NPAT_XENLA              Reviewed;        1356 AA.
AC   A2RRX6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Protein NPAT;
GN   Name=npat;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for progression through the G1 and S phases of the
CC       cell cycle and for S phase entry. Activates transcription of the
CC       histone H2A, histone H2B, histone H3 and histone H4 genes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The LisH domain is required for the activation of histone gene
CC       transcription. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPAT family. {ECO:0000305}.
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DR   EMBL; BC131895; AAI31896.1; -; mRNA.
DR   RefSeq; NP_001091302.1; NM_001097833.1.
DR   AlphaFoldDB; A2RRX6; -.
DR   SMR; A2RRX6; -.
DR   MaxQB; A2RRX6; -.
DR   PRIDE; A2RRX6; -.
DR   GeneID; 100037125; -.
DR   KEGG; xla:100037125; -.
DR   CTD; 100037125; -.
DR   Xenbase; XB-GENE-6255262; npat.S.
DR   OrthoDB; 80675at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100037125; Expressed in testis and 19 other tissues.
DR   GO; GO:0015030; C:Cajal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0097504; C:Gemini of coiled bodies; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR031442; NPAT_C.
DR   Pfam; PF15712; NPAT_C; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cell cycle; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1356
FT                   /note="Protein NPAT"
FT                   /id="PRO_0000318165"
FT   DOMAIN          3..35
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          180..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          916..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1107..1130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1180..1258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1276..1342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..440
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..631
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        940..993
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1005..1044
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1067
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1206..1228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1276..1292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1295..1322
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1356 AA;  145668 MW;  4E79116D97E1EFA6 CRC64;
     MLLPSDVARL VLGYLQQEKL SSTCRSFILE SPNLREYAEH YTDEGSIPGC VLSLFGKNLT
     TILNEYIAMK AKENKEEIPV MVSALWKKLD HTLSQIRSMQ NCLVLPTSQK VRTRYGIQDL
     RHQRMLTSHA ASTGSAVALQ QTSTPIAAKQ VMLRSFTSQS ASQTIVSPLC SGQSTIQCTN
     SPATESKGET LQNSALSDAE KKQTSSPMRR KTDCQRRRRA APLNSSSATH EGETEGNVDS
     LQDLIDGNFP QLVIENAREK ILSNKSLQEK LAENINKFLG SDTATQASKL SEGGALEQYT
     SIDEILGLQG GEMHMSEEAI HDILEQTELD PDFQELYDLF ACSSTKPTKL ASRDPSLQTE
     GVATTSIHVA NDNLEPMESS FDASVDTSHS SNHSEVGAAQ KKDGRSQLVV PSPTPKVTES
     TGMPSKVQEM PISASERQSM SDRSVESKKS IDSVIILDNT GSDTVIESNE EVQVTSMEVG
     ISQSQDVDMN VLHTEVIGAD CQLAVEQGSL NMLTVDLTVP NLKEETPKMQ TYEKASEAKK
     SSPLKDEVQA LGSRRLERNK SEGAEGPCTT ESQNIVVLVS IGSTVTESNL LNQRGDLPAT
     PRKTDTSTET TVSEQMQAES SITSKELKVL QKQASKTPPH PMVPPISPSI KGSSSDSDGS
     SLPLEVSSSV GVSTPVNTSN VEQNCSDVSS VDPSQIITLS FITEDIAEDA ELTKAVKSIS
     ERSNSALLLS PFHKPQESSS IVSIPGPTSE TLTLLADPRE VVNVSGDVAT GVKPAEDCTI
     ISLPGASNLS TDGGIIQLMP ATSSSFAPSG SFFISTCNTG GAQQSNIMVV PSNCAPASTQ
     KQPCHFQTPP RPHSVYTVGQ AISPKLSQGS TFILASAVQP VLPGVMGMFP VSVVGQSSNT
     FTTPSHQVLH VPVSQGVPKL SLPPKSQKPV PPRTLASAAE KQGTAATTDS GNRKSSSRMQ
     RSENVDKNLA AMSQNKPEER QTSTTNPSTK GTENHKRVLC FENTAANRGT PNTKSLCNSA
     APQNKDKVET MNTSSSSLPA KQNNKDSGKA DKTAPSTEAN SKCESVPSKQ PVVPATKDLS
     GDKKPVAVAS SPDVLGGVMA NKENMLQKEN KKQELPEVSK KSSTADGAAG NLERTVQAVH
     ETGRKHATLP SILRRTKLST ERMCPPSPLT KQASDLLQSM QFNSPNAKHF SGGDLPIPRT
     PGSGIDDRLV DSHQDHMKTP KSKRYPEDGG TPKPMLPPAT PELPACSPAS ETGSENSVNM
     AAHTLMILSR ATLAKTDGSS PLKDNTQQIK LSKNSSKKRK LDEPDEYGRR PHKKELMSPS
     AILKRKKMKK HRKKSTDDFP AGMDVDKFLM SLHYDE