NPB11_HUMAN
ID NPB11_HUMAN Reviewed; 1161 AA.
AC E5RHQ5;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Nuclear pore complex-interacting protein family member B11;
GN Name=NPIPB11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR EMBL; AC025279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RHQ5; -.
DR STRING; 9606.ENSP00000430853; -.
DR iPTMnet; E5RHQ5; -.
DR PhosphoSitePlus; E5RHQ5; -.
DR BioMuta; NPIPB11; -.
DR jPOST; E5RHQ5; -.
DR MassIVE; E5RHQ5; -.
DR PaxDb; E5RHQ5; -.
DR PeptideAtlas; E5RHQ5; -.
DR PRIDE; E5RHQ5; -.
DR Ensembl; ENST00000524087.5; ENSP00000430853.1; ENSG00000254206.5.
DR UCSC; uc059ssm.1; human.
DR GeneCards; NPIPB11; -.
DR HGNC; HGNC:37453; NPIPB11.
DR HPA; ENSG00000254206; Low tissue specificity.
DR neXtProt; NX_E5RHQ5; -.
DR OpenTargets; ENSG00000254206; -.
DR VEuPathDB; HostDB:ENSG00000254206; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_308511_0_0_1; -.
DR InParanoid; E5RHQ5; -.
DR OMA; LWTHLQP; -.
DR PhylomeDB; E5RHQ5; -.
DR TreeFam; TF333389; -.
DR ChiTaRS; NPIPB11; human.
DR Pharos; E5RHQ5; Tdark.
DR PRO; PR:E5RHQ5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; E5RHQ5; protein.
DR Bgee; ENSG00000254206; Expressed in right hemisphere of cerebellum and 92 other tissues.
DR ExpressionAtlas; E5RHQ5; baseline and differential.
DR Genevisible; E5RHQ5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 6.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1161
FT /note="Nuclear pore complex-interacting protein family
FT member B11"
FT /id="PRO_0000423924"
FT TRANSMEM 63..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 278..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 129208 MW; AC00E5D9C13E65FF CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
LHIIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHCITDNS LSLKTPLECL LTPLPPSADD NLKTPPECLL TPLPPSADDN
LKTPPECLLT PLPPSAPPSA PPSADDNLKT RAECLLHPLP PSADDNLKTP SERQLTPLPP
SAPPSADDNI KTTAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAEHLR
GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPSERQ
LTPLPPSAPP SADDNIKTPA EHLRGPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT
TAEHLRGPLP PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAEHLQFR FHPQRMIISR
DLPSVSSLPF HPQLHPQQMI ISRYLLSICG FRFHRQRMII SRHLPSVSSL PFHPQLHPQQ
MIISRHLPSV CGGRFHPQPM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ
PMIISRHLPS VSSLPFHPQL HPQQMIISRH LPSVCGGRFH PQPMIISRHL PSVSSLPFHP
QLHPQQMIIS RHLPSVCGGR FHPQPMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG
GRFHPQPMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV CGERLWVPLP PSADDNLKTP
SKRQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSKRQLTPL PPSAPPSADD
NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD
DNLKTPSERQ LTPLPPSAPT SADDNIKTPA ERLRGPLPPS ADDNLKTPPL ATQEAEAEKP
RKPKRQRAAE MEPPPEPKRR RVGDVEPSRK PKRRRAADVE PSSPEPKRRR VGDVEPSRKP
KRRRAADVEP SSPEPKRRRL S
