ID   NPB12_HUMAN             Reviewed;         928 AA.
AC   F8W0I5;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Nuclear pore complex-interacting protein family member B12 {ECO:0000305};
GN   Name=NPIPB12 {ECO:0000312|HGNC:HGNC:37491};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR   EMBL; AC133555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F8W0I5; -.
DR   MassIVE; F8W0I5; -.
DR   PeptideAtlas; F8W0I5; -.
DR   PRIDE; F8W0I5; -.
DR   Ensembl; ENST00000550665.5; ENSP00000447597.1; ENSG00000169203.17.
DR   UCSC; uc021tgb.2; human.
DR   GeneCards; NPIPB12; -.
DR   HGNC; HGNC:37491; NPIPB12.
DR   HPA; ENSG00000169203; Tissue enhanced (brain).
DR   neXtProt; NX_F8W0I5; -.
DR   VEuPathDB; HostDB:ENSG00000169203; -.
DR   eggNOG; ENOG502TDBV; Eukaryota.
DR   HOGENOM; CLU_458991_0_0_1; -.
DR   PRO; PR:F8W0I5; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000169203; Expressed in right hemisphere of cerebellum and 93 other tissues.
DR   ExpressionAtlas; F8W0I5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   InterPro; IPR009443; NPIP.
DR   PANTHER; PTHR15438; PTHR15438; 4.
DR   Pfam; PF06409; NPIP; 2.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..928
FT                   /note="Nuclear pore complex-interacting protein family
FT                   member B12"
FT                   /id="PRO_0000450480"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          242..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          663..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..359
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        813..928
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  104040 MW;  89335268F5BAD3E7 CRC64;
     MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
     LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
     ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
     KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
     NRMGHQPPPP TQQHSITDNS LSLKTPPECV LTPLPPSADD NLKTPPECVL TPLPPSADDN
     LKTPPECLLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSAPPSAPP
     SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
     PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAFHPQRM IISRHLPSVS SLPFHPQLHS
     QQMIISRYLL SVCGFRFHHQ PMIISRHLPS VSSLPFHPQL HPQQMIISRH LPSVCGGRFH
     PQRMIISRHL PSVSSLPFHP QLHPQQMIIS RHLPSVCGGR FHPQRMIISR HLPSVSSLPF
     HPQLHPQQMI ISRHLPSVCG GRFHPQRMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV
     CGERLRGPLP PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK
     TPSERQLTPL PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA
     DDNIKTPAER LRGPLPPSAD DNLKTPPLAT QEAEAEKPRK PKRQRAAEME PPPEPKRRRV
     GDVEPSRKPK RRRAADVEPS SPEPKRRRVG DVEPSRKPKR RRAADVEPSS PEPKRRRVGD
     VEPSRKPKRR RAADVEPSLP EPKRRRLS