NPB13_HUMAN
ID NPB13_HUMAN Reviewed; 1138 AA.
AC A6NJU9;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 4.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Nuclear pore complex-interacting protein family member B13 {ECO:0000312|HGNC:HGNC:41989};
GN Name=NPIPB13 {ECO:0000312|HGNC:HGNC:41989};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC106782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS81968.1; -.
DR RefSeq; NP_001308821.1; NM_001321892.1.
DR AlphaFoldDB; A6NJU9; -.
DR SMR; A6NJU9; -.
DR BioMuta; NPIPB13; -.
DR jPOST; A6NJU9; -.
DR MassIVE; A6NJU9; -.
DR PaxDb; A6NJU9; -.
DR PeptideAtlas; A6NJU9; -.
DR PRIDE; A6NJU9; -.
DR Ensembl; ENST00000520915.5; ENSP00000429734.1; ENSG00000198064.14.
DR GeneID; 613037; -.
DR KEGG; hsa:613037; -.
DR UCSC; uc010vem.3; human.
DR CTD; 613037; -.
DR GeneCards; NPIPB13; -.
DR HGNC; HGNC:41989; NPIPB13.
DR HPA; ENSG00000198064; Low tissue specificity.
DR neXtProt; NX_A6NJU9; -.
DR VEuPathDB; HostDB:ENSG00000198064; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_308511_0_0_1; -.
DR OMA; ETTSELC; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; A6NJU9; -.
DR PathwayCommons; A6NJU9; -.
DR SignaLink; A6NJU9; -.
DR BioGRID-ORCS; 613037; 0 hits in 7 CRISPR screens.
DR ChiTaRS; NPIPB13; human.
DR GenomeRNAi; 613037; -.
DR Pharos; A6NJU9; Tdark.
DR PRO; PR:A6NJU9; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A6NJU9; protein.
DR Bgee; ENSG00000198064; Expressed in sural nerve and 100 other tissues.
DR ExpressionAtlas; A6NJU9; baseline and differential.
DR Genevisible; A6NJU9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 6.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1138
FT /note="Nuclear pore complex-interacting protein family
FT member B13"
FT /id="PRO_0000343665"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 242..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 125964 MW; D5FB190502A78C8D CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSITDNS LSLKTPPECV LTPLPPSADD NLKTPPECVL TPLPPSADDN
LKTPPECLLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSAPPSAPP
SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER
LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA FHPQRMIISR HLPSVSSLPF
HPQLHSQQMI ISRYLLSVCG FRFHHQPMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV
CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ RMIISRHLPS
VSSLPFHPQL HPQQMIISRH LPSVCGERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA
DDNIKTPAER LRRPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA ERLRGPLPPS
ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP PSADDNLKTP SERQLTPLPP
SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR
GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPPLAT
QEAEAEKPRK PKRQRAAEME PPPEPKRRRV GDVEPSRKPK RRRAADVEPS SPKPKRRRVG
DVEPSRKPKR RRAADVEPSS PEPKRRRVGD VEPSRKPKRR RAADVEPSSP EPKRRRLS
