NPB15_HUMAN
ID NPB15_HUMAN Reviewed; 443 AA.
AC A6NHN6; C9J9U8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Nuclear pore complex-interacting protein family member B15;
DE AltName: Full=Nuclear pore complex-interacting protein-like 2;
DE Flags: Precursor;
GN Name=NPIPB15; Synonyms=NPIPL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR EMBL; AC009053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS76897.1; -.
DR RefSeq; NP_001293023.1; NM_001306094.1.
DR RefSeq; XP_011521800.1; XM_011523498.2.
DR RefSeq; XP_016878737.1; XM_017023248.1.
DR AlphaFoldDB; A6NHN6; -.
DR IntAct; A6NHN6; 1.
DR STRING; 9606.ENSP00000411140; -.
DR GlyGen; A6NHN6; 1 site.
DR iPTMnet; A6NHN6; -.
DR PhosphoSitePlus; A6NHN6; -.
DR BioMuta; NPIPB15; -.
DR MassIVE; A6NHN6; -.
DR PaxDb; A6NHN6; -.
DR PeptideAtlas; A6NHN6; -.
DR PRIDE; A6NHN6; -.
DR Antibodypedia; 71489; 27 antibodies from 11 providers.
DR DNASU; 440348; -.
DR Ensembl; ENST00000429990.1; ENSP00000411140.1; ENSG00000196436.9.
DR Ensembl; ENST00000692376.1; ENSP00000508772.1; ENSG00000196436.9.
DR GeneID; 440348; -.
DR KEGG; hsa:440348; -.
DR MANE-Select; ENST00000692376.1; ENSP00000508772.1; NM_001306094.2; NP_001293023.1.
DR UCSC; uc059xbq.1; human.
DR CTD; 440348; -.
DR DisGeNET; 440348; -.
DR GeneCards; NPIPB15; -.
DR HGNC; HGNC:34409; NPIPB15.
DR HPA; ENSG00000196436; Tissue enhanced (testis).
DR neXtProt; NX_A6NHN6; -.
DR VEuPathDB; HostDB:ENSG00000196436; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_059939_0_0_1; -.
DR InParanoid; A6NHN6; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; A6NHN6; -.
DR TreeFam; TF333389; -.
DR PathwayCommons; A6NHN6; -.
DR SignaLink; A6NHN6; -.
DR BioGRID-ORCS; 440348; 8 hits in 69 CRISPR screens.
DR ChiTaRS; NPIPB15; human.
DR GenomeRNAi; 440348; -.
DR Pharos; A6NHN6; Tdark.
DR PRO; PR:A6NHN6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A6NHN6; protein.
DR Bgee; ENSG00000196436; Expressed in right testis and 101 other tissues.
DR Genevisible; A6NHN6; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 2.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..443
FT /note="Nuclear pore complex-interacting protein family
FT member B15"
FT /id="PRO_0000367122"
FT REGION 242..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 443 AA; 51267 MW; BC563993652FEAFF CRC64;
MRLRFWLLIW LLLGFISHQP TPVINSLAVY RHRETDFGVG VRDHPGQHGK TPSPQKLDNL
IIIIIGFLRR DTFTILFCTS YLCVSFLKTI FWSRNGHDGS TDVQQRAWRS NRSRQKGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKP LCNWVRMAAA EHRHSSGLPC WPYLTAEALK
NRMGRQPPPP TQQHSITDNS LSLKTPPECL LHPLPPSVDD NIKECPLAPL PPSVDDNLKE
YLLVPLPPSP LPPSVDDNLK DCLFVPLPPS PLPPSVDDNL KTPPLATQEA EAEKPPKPKR
WRVDEVEQSP KPKRRRADEV EQSPKPKRQR EAEAQQLPKP KRRRLSKLRT RHCTQAWAIR
INPWVEKKKK IKKQNKTHAP KTN
