NPBW1_MOUSE
ID NPBW1_MOUSE Reviewed; 329 AA.
AC P49681;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Neuropeptides B/W receptor type 1;
DE AltName: Full=G-protein coupled receptor 7;
GN Name=Npbwr1; Synonyms=Gpr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-221.
RX PubMed=7590751; DOI=10.1006/geno.1995.1109;
RA O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S.,
RA Marchese A., Zastawny R., Heng H.H.Q., Tsui L.-C., Shi X., Asa S., Puy L.,
RA George S.R.;
RT "The cloning and chromosomal mapping of two novel human opioid-
RT somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete
RT areas of the brain.";
RL Genomics 28:84-91(1995).
CC -!- FUNCTION: Interacts specifically with a number of opioid ligands.
CC Receptor for neuropeptides B and W, which may be involved in
CC neuroendocrine system regulation, food intake and the organization of
CC other signals (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC118196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U23807; AAA86386.1; -; Genomic_DNA.
DR CCDS; CCDS48214.1; -.
DR RefSeq; NP_034472.1; NM_010342.1.
DR AlphaFoldDB; P49681; -.
DR SMR; P49681; -.
DR STRING; 10090.ENSMUSP00000046233; -.
DR BindingDB; P49681; -.
DR ChEMBL; CHEMBL1938219; -.
DR GlyGen; P49681; 3 sites.
DR iPTMnet; P49681; -.
DR PhosphoSitePlus; P49681; -.
DR PaxDb; P49681; -.
DR PRIDE; P49681; -.
DR Antibodypedia; 82634; 218 antibodies from 29 providers.
DR Ensembl; ENSMUST00000044180; ENSMUSP00000046233; ENSMUSG00000033774.
DR GeneID; 226304; -.
DR KEGG; mmu:226304; -.
DR UCSC; uc011whw.1; mouse.
DR CTD; 2831; -.
DR MGI; MGI:891989; Npbwr1.
DR VEuPathDB; HostDB:ENSMUSG00000033774; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161936; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; P49681; -.
DR OMA; PESVWWK; -.
DR OrthoDB; 1011272at2759; -.
DR PhylomeDB; P49681; -.
DR TreeFam; TF315737; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 226304; 1 hit in 70 CRISPR screens.
DR PRO; PR:P49681; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P49681; protein.
DR Bgee; ENSMUSG00000033774; Expressed in lip and 12 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:InterPro.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0019222; P:regulation of metabolic process; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009150; Neuropept_B/W_rcpt.
DR InterPro; IPR027348; NPBW1.
DR PANTHER; PTHR24229:SF47; PTHR24229:SF47; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01855; NRPEPTIDEWR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="Neuropeptides B/W receptor type 1"
FT /id="PRO_0000069519"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 329 AA; 36076 MW; F6100C1F58377EDE CRC64;
MHNLTLFESG GDNVSCGGSS LGCPNGSSLA PLPLPQPLAV AVPVVYGVIC AVGLAGNSAV
LYVLLRTPRM KTVTNVFILN LAIADELFTL VLPINIADFL LRRWPFGEVM CKLIVAVDQY
NTFSSLYFLA VMSADRYLVV LATAESRRVS GRTYGAARAV SLAVWALVTL VVLPFAVFAR
LDEEQGRRQC VLVFPQPEAF WWRASRLYTL VLGFAIPVTT ICALYTTLLC RLRAIQLDSH
AKALDRAKKR VTLLVAAILA VCLLCWTPYH LSTIVALTTD LPQTPLVIGI SYFITSLSYA
NSCLNPFLYA FLDDSFRRSL RQLVSCRSA
