NPBW2_BOVIN
ID NPBW2_BOVIN Reviewed; 336 AA.
AC Q8MJV2;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Neuropeptides B/W receptor type 2;
DE AltName: Full=G-protein coupled receptor 8;
GN Name=NPBWR2; Synonyms=GPR8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12118011; DOI=10.1074/jbc.m205883200;
RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y.,
RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.;
RT "Identification of a neuropeptide modified with bromine as an endogenous
RT ligand for GPR7.";
RL J. Biol. Chem. 277:34010-34016(2002).
CC -!- FUNCTION: Interacts specifically with a number of opioid ligands.
CC Receptor for neuropeptides B and W, which may be involved in
CC neuroendocrine system regulation, food intake and the organization of
CC other signals (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB085947; BAC07180.1; -; mRNA.
DR RefSeq; NP_776500.1; NM_174075.1.
DR AlphaFoldDB; Q8MJV2; -.
DR SMR; Q8MJV2; -.
DR STRING; 9913.ENSBTAP00000054391; -.
DR PaxDb; Q8MJV2; -.
DR Ensembl; ENSBTAT00000065755; ENSBTAP00000054391; ENSBTAG00000047704.
DR GeneID; 281208; -.
DR KEGG; bta:281208; -.
DR CTD; 2832; -.
DR VEuPathDB; HostDB:ENSBTAG00000047704; -.
DR VGNC; VGNC:106846; NPBWR2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163127; -.
DR InParanoid; Q8MJV2; -.
DR OMA; IISFCVW; -.
DR OrthoDB; 1011272at2759; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000047704; Expressed in floor plate of diencephalon and 4 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:InterPro.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009150; Neuropept_B/W_rcpt.
DR InterPro; IPR027349; NPBW2.
DR PANTHER; PTHR24229:SF18; PTHR24229:SF18; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01855; NRPEPTIDEWR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Neuropeptides B/W receptor type 2"
FT /id="PRO_0000069521"
FT TOPO_DOM 1..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..236
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..279
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..316
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 117..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 336 AA; 36727 MW; 98E346053518891B CRC64;
MMEATGLEGL ESTSSPCPGS TGTGLSWDNG TRHNATFPEP LPALYVLLPV VYSVICAVGL
VGNAAVICVI LRAPKMKTVT HVFILNLAIA DGLFTLVLPT NIAEHLLQRW PFGEVLCKLV
LAIDHCNIFS SVYFLAAMSI DRYLVVLATA RSRRMPRRTV HRAKVASLCV WLGVTVAVLP
FLTFAGVYNN ELQVTSCGLS FPRPERAWFQ ASRIYTLVLG FVVPMCTLCV LYADLLRRLR
ALRLHSGAKA LGKAKRKVSL LVLAVLAVGL LCWTPFHLAS IVALTTDLPQ TPLVIIVSYV
VTSLSYTSSC LNPFLYAFLD HSFRKSLRTA CRCQGA
