ID   NPB_BOVIN               Reviewed;         122 AA.
AC   Q8MJV4;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Neuropeptide B;
DE   AltName: Full=Preproprotein L7;
DE   AltName: Full=bPPL7;
DE   Contains:
DE     RecName: Full=Neuropeptide B-29;
DE              Short=NPB29;
DE     AltName: Full=L7C;
DE   Flags: Precursor;
GN   Name=NPB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-49, AND BROMINATION AT
RP   TRP-25.
RX   PubMed=12118011; DOI=10.1074/jbc.m205883200;
RA   Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y.,
RA   Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.;
RT   "Identification of a neuropeptide modified with bromine as an endogenous
RT   ligand for GPR7.";
RL   J. Biol. Chem. 277:34010-34016(2002).
RN   [2]
RP   CHARACTERIZATION, AND BROMINATION AT TRP-25.
RX   PubMed=12719537; DOI=10.1073/pnas.0837789100;
RA   Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K.,
RA   Yamanaka A., Williams S.C., Richardson J.A., Tsujino N., Garry M.G.,
RA   Lerner M.R., King D.S., O'Dowd B.F., Sakurai T., Yanagisawa M.;
RT   "Characterization of a family of endogenous neuropeptide ligands for the G
RT   protein-coupled receptors GPR7 and GPR8.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:6251-6256(2003).
CC   -!- FUNCTION: May be involved in the regulation of feeding, neuroendocrine
CC       system, memory, learning and in the afferent pain pathway.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB085943; BAC07176.1; -; mRNA.
DR   RefSeq; NP_776369.1; NM_173944.1.
DR   AlphaFoldDB; Q8MJV4; -.
DR   STRING; 9913.ENSBTAP00000018455; -.
DR   PaxDb; Q8MJV4; -.
DR   Ensembl; ENSBTAT00000018455; ENSBTAP00000018455; ENSBTAG00000013898.
DR   GeneID; 280880; -.
DR   KEGG; bta:280880; -.
DR   CTD; 256933; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013898; -.
DR   VGNC; VGNC:32192; NPB.
DR   eggNOG; ENOG502S25S; Eukaryota.
DR   GeneTree; ENSGT00940000158204; -.
DR   HOGENOM; CLU_1991876_0_0_1; -.
DR   InParanoid; Q8MJV4; -.
DR   OMA; KSMAICV; -.
DR   OrthoDB; 1581012at2759; -.
DR   TreeFam; TF333179; -.
DR   Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-BTA-418594; G alpha (i) signalling events.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000013898; Expressed in floor plate of diencephalon and 45 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013298; Neuropept_B_pre.
DR   InterPro; IPR013297; Neuropept_BW_pre.
DR   PANTHER; PTHR28553; PTHR28553; 1.
DR   Pfam; PF15180; NPBW; 1.
DR   PRINTS; PR01888; NROPEPTIDEBW.
DR   PRINTS; PR01889; PPNRPEPTIDEB.
PE   1: Evidence at protein level;
KW   Bromination; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:12118011"
FT   PEPTIDE         25..53
FT                   /note="Neuropeptide B-29"
FT                   /id="PRO_0000019834"
FT   PROPEP          56..122
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019835"
FT   MOD_RES         25
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000269|PubMed:12118011,
FT                   ECO:0000269|PubMed:12719537"
SQ   SEQUENCE   122 AA;  12919 MW;  62EEAE117840D118 CRC64;
     MAGPAMLVAA ALALCLLLAS PGLAWYKPTA GQGYYSVGRA AGLLSGFHRS PYARRSEPRG
     GTRSLGGVGT FREMRPNLRS LAVCVEEVTP NLQSCEPLPD GRATFQCKAD VFLSLSASDC
     RK