NPB_HUMAN
ID NPB_HUMAN Reviewed; 125 AA.
AC Q8NG41; A0AUX9; A6NJD6; B9EJC3;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Neuropeptide B;
DE AltName: Full=Preproprotein L7;
DE Short=hPPL7;
DE Contains:
DE RecName: Full=Neuropeptide B-23;
DE Short=NPB23;
DE Short=hL7;
DE Contains:
DE RecName: Full=Neuropeptide B-29;
DE Short=NPB29;
DE Short=hL7C;
DE Flags: Precursor;
GN Name=NPB; Synonyms=PPL7, PPNPB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-48, AND SYNTHESIS OF
RP NPB23.
RX PubMed=12118011; DOI=10.1074/jbc.m205883200;
RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y.,
RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.;
RT "Identification of a neuropeptide modified with bromine as an endogenous
RT ligand for GPR7.";
RL J. Biol. Chem. 277:34010-34016(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=12401809; DOI=10.1074/jbc.m206396200;
RA Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V.,
RA Lucchetti J., Detheux M., Parmentier M.;
RT "Identification of natural ligands for the orphan G protein-coupled
RT receptors GPR7 and GPR8.";
RL J. Biol. Chem. 278:776-783(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the regulation of feeding, neuroendocrine
CC system, memory, learning and in the afferent pain pathway.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Widely expressed in the central nervous system.
CC High levels are found in substantia nigra, hypothalamus, hippocampus,
CC spinal cord, placenta and fetal brain; lower levels are found in
CC testis, uterus and ovary. Also detected at high levels in colorectal
CC adenocarcinoma.
CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB085942; BAC07175.1; -; mRNA.
DR EMBL; AF525737; AAP80794.1; -; mRNA.
DR EMBL; AF525738; AAP80795.1; -; Transcribed_RNA.
DR EMBL; AL360181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126128; AAI26129.1; -; mRNA.
DR EMBL; BC126485; AAI26486.1; -; mRNA.
DR EMBL; BC146875; AAI46876.1; -; mRNA.
DR EMBL; BC146890; AAI46891.1; -; mRNA.
DR CCDS; CCDS11790.1; -.
DR RefSeq; NP_683694.1; NM_148896.4.
DR AlphaFoldDB; Q8NG41; -.
DR BioGRID; 129184; 33.
DR IntAct; Q8NG41; 26.
DR STRING; 9606.ENSP00000332766; -.
DR iPTMnet; Q8NG41; -.
DR PhosphoSitePlus; Q8NG41; -.
DR BioMuta; NPB; -.
DR MassIVE; Q8NG41; -.
DR PaxDb; Q8NG41; -.
DR PeptideAtlas; Q8NG41; -.
DR PRIDE; Q8NG41; -.
DR ProteomicsDB; 73419; -.
DR Antibodypedia; 32928; 40 antibodies from 16 providers.
DR DNASU; 256933; -.
DR Ensembl; ENST00000333383.8; ENSP00000332766.7; ENSG00000183979.8.
DR GeneID; 256933; -.
DR KEGG; hsa:256933; -.
DR MANE-Select; ENST00000333383.8; ENSP00000332766.7; NM_148896.5; NP_683694.1.
DR UCSC; uc002kcd.4; human.
DR CTD; 256933; -.
DR DisGeNET; 256933; -.
DR GeneCards; NPB; -.
DR HGNC; HGNC:30099; NPB.
DR HPA; ENSG00000183979; Tissue enriched (brain).
DR MIM; 607996; gene.
DR neXtProt; NX_Q8NG41; -.
DR OpenTargets; ENSG00000183979; -.
DR PharmGKB; PA142671255; -.
DR VEuPathDB; HostDB:ENSG00000183979; -.
DR eggNOG; ENOG502S25S; Eukaryota.
DR GeneTree; ENSGT00940000158204; -.
DR HOGENOM; CLU_1991876_0_0_1; -.
DR InParanoid; Q8NG41; -.
DR PhylomeDB; Q8NG41; -.
DR TreeFam; TF333179; -.
DR PathwayCommons; Q8NG41; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q8NG41; -.
DR BioGRID-ORCS; 256933; 200 hits in 1013 CRISPR screens.
DR GenomeRNAi; 256933; -.
DR Pharos; Q8NG41; Tdark.
DR PRO; PR:Q8NG41; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8NG41; protein.
DR Bgee; ENSG00000183979; Expressed in C1 segment of cervical spinal cord and 105 other tissues.
DR ExpressionAtlas; Q8NG41; baseline and differential.
DR Genevisible; Q8NG41; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:HGNC-UCL.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013298; Neuropept_B_pre.
DR InterPro; IPR013297; Neuropept_BW_pre.
DR PANTHER; PTHR28553; PTHR28553; 1.
DR Pfam; PF15180; NPBW; 1.
DR PRINTS; PR01888; NROPEPTIDEBW.
DR PRINTS; PR01889; PPNRPEPTIDEB.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PEPTIDE 25..53
FT /note="Neuropeptide B-29"
FT /id="PRO_0000019836"
FT PEPTIDE 25..48
FT /note="Neuropeptide B-23"
FT /id="PRO_0000019837"
FT PROPEP 56..125
FT /evidence="ECO:0000255"
FT /id="PRO_0000019838"
FT REGION 54..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 125 AA; 13097 MW; 98CBFAB33B42AC90 CRC64;
MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR
GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA
DCLAA
