NPB_MOUSE
ID NPB_MOUSE Reviewed; 119 AA.
AC Q8K4P1;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Neuropeptide B;
DE AltName: Full=Preproprotein L7;
DE Short=mPPL7;
DE Contains:
DE RecName: Full=Neuropeptide B-29;
DE Short=NPB29;
DE AltName: Full=L7C;
DE Flags: Precursor;
GN Name=Npb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12118011; DOI=10.1074/jbc.m205883200;
RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y.,
RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.;
RT "Identification of a neuropeptide modified with bromine as an endogenous
RT ligand for GPR7.";
RL J. Biol. Chem. 277:34010-34016(2002).
RN [2]
RP CHARACTERIZATION, AND TISSUE SPECIFICITY.
RX PubMed=12719537; DOI=10.1073/pnas.0837789100;
RA Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K.,
RA Yamanaka A., Williams S.C., Richardson J.A., Tsujino N., Garry M.G.,
RA Lerner M.R., King D.S., O'Dowd B.F., Sakurai T., Yanagisawa M.;
RT "Characterization of a family of endogenous neuropeptide ligands for the G
RT protein-coupled receptors GPR7 and GPR8.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:6251-6256(2003).
CC -!- FUNCTION: Has an effect in food intake, on locomotor activity and has
CC an analgesic effect, (in vivo pharmacological studies). May be involved
CC in the regulation of neuroendocrine system, memory and learning (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Detected in brain; more specifically in
CC paraventricular hypothalamic nucleus, hippocampus and several nuclei in
CC midbrain and brainstem. {ECO:0000269|PubMed:12719537}.
CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
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DR EMBL; AB085945; BAC07178.1; -; mRNA.
DR CCDS; CCDS25746.1; -.
DR RefSeq; NP_695020.1; NM_153288.3.
DR AlphaFoldDB; Q8K4P1; -.
DR STRING; 10090.ENSMUSP00000101801; -.
DR iPTMnet; Q8K4P1; -.
DR PhosphoSitePlus; Q8K4P1; -.
DR PaxDb; Q8K4P1; -.
DR PRIDE; Q8K4P1; -.
DR ProteomicsDB; 293712; -.
DR Antibodypedia; 32928; 40 antibodies from 16 providers.
DR Ensembl; ENSMUST00000106195; ENSMUSP00000101801; ENSMUSG00000044034.
DR GeneID; 208990; -.
DR KEGG; mmu:208990; -.
DR UCSC; uc007mto.1; mouse.
DR CTD; 256933; -.
DR MGI; MGI:2387153; Npb.
DR VEuPathDB; HostDB:ENSMUSG00000044034; -.
DR eggNOG; ENOG502S25S; Eukaryota.
DR GeneTree; ENSGT00940000158204; -.
DR InParanoid; Q8K4P1; -.
DR OMA; VQCAMER; -.
DR OrthoDB; 1581012at2759; -.
DR PhylomeDB; Q8K4P1; -.
DR TreeFam; TF333179; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 208990; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q8K4P1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8K4P1; protein.
DR Bgee; ENSMUSG00000044034; Expressed in stomach and 58 other tissues.
DR ExpressionAtlas; Q8K4P1; baseline and differential.
DR Genevisible; Q8K4P1; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013298; Neuropept_B_pre.
DR InterPro; IPR013297; Neuropept_BW_pre.
DR PANTHER; PTHR28553; PTHR28553; 1.
DR Pfam; PF15180; NPBW; 1.
DR PRINTS; PR01888; NROPEPTIDEBW.
DR PRINTS; PR01889; PPNRPEPTIDEB.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PEPTIDE 22..50
FT /note="Neuropeptide B-29"
FT /id="PRO_0000019839"
FT PROPEP 53..119
FT /evidence="ECO:0000255"
FT /id="PRO_0000019840"
SQ SEQUENCE 119 AA; 13018 MW; AFC5531BCF884224 CRC64;
MARCRTLVAA ALALLLPPAL AWYKPAAGPH HYSVGRASGL LSSFHRFPST RRSESPALRV
GTGPLRNLEM RPSVRSLALC VKDVTPNLQS CQRQLNSRGT FQCKADVFLS LHETDCQST
