ID   NPB_RAT                 Reviewed;         119 AA.
AC   Q8K4P2;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Neuropeptide B;
DE   AltName: Full=Preproprotein L7;
DE            Short=rPPL7;
DE   Contains:
DE     RecName: Full=Neuropeptide B-29;
DE              Short=NPB29;
DE     AltName: Full=L7C;
DE   Flags: Precursor;
GN   Name=Npb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12118011; DOI=10.1074/jbc.m205883200;
RA   Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y.,
RA   Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.;
RT   "Identification of a neuropeptide modified with bromine as an endogenous
RT   ligand for GPR7.";
RL   J. Biol. Chem. 277:34010-34016(2002).
CC   -!- FUNCTION: May be involved in the regulation of feeding, neuroendocrine
CC       system, memory and learning. May be involved in the afferent pain
CC       pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Detected in a variety of tissues. High levels are
CC       found in the lymphoid organs, central nervous system, mammary gland and
CC       uterus.
CC   -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
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DR   EMBL; AB085944; BAC07177.1; -; mRNA.
DR   RefSeq; NP_695205.1; NM_153293.1.
DR   AlphaFoldDB; Q8K4P2; -.
DR   STRING; 10116.ENSRNOP00000051836; -.
DR   PaxDb; Q8K4P2; -.
DR   Ensembl; ENSRNOT00000054954; ENSRNOP00000051837; ENSRNOG00000036686.
DR   GeneID; 259222; -.
DR   KEGG; rno:259222; -.
DR   CTD; 256933; -.
DR   RGD; 708513; Npb.
DR   eggNOG; ENOG502S25S; Eukaryota.
DR   GeneTree; ENSGT00940000158204; -.
DR   HOGENOM; CLU_1991876_0_0_1; -.
DR   InParanoid; Q8K4P2; -.
DR   OMA; VQCAMER; -.
DR   OrthoDB; 1581012at2759; -.
DR   PhylomeDB; Q8K4P2; -.
DR   TreeFam; TF333179; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:Q8K4P2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000036685; Expressed in spleen and 17 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IMP:RGD.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013298; Neuropept_B_pre.
DR   InterPro; IPR013297; Neuropept_BW_pre.
DR   PANTHER; PTHR28553; PTHR28553; 1.
DR   Pfam; PF15180; NPBW; 1.
DR   PRINTS; PR01888; NROPEPTIDEBW.
DR   PRINTS; PR01889; PPNRPEPTIDEB.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..50
FT                   /note="Neuropeptide B-29"
FT                   /id="PRO_0000019841"
FT   PROPEP          53..119
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019842"
SQ   SEQUENCE   119 AA;  13019 MW;  6C2F5B9E6251CAC6 CRC64;
     MVRCRTLVAA ALALLLTPAL AWYKPAAGSH HYSVGRAAGL LSSFHRFPST RRSESPALRV
     GTVPLRNLEM RPSVRSLALC VKDVTPNLQS CQRQLNSRGT FQCKADVFLS LHKAECQSA