ID   NPC22_DICDI             Reviewed;         142 AA.
AC   Q54SZ8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative phosphatidylglycerol/phosphatidylinositol transfer protein 2;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0282109;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000045; EAL66380.1; -; Genomic_DNA.
DR   RefSeq; XP_640357.1; XM_635265.1.
DR   AlphaFoldDB; Q54SZ8; -.
DR   SMR; Q54SZ8; -.
DR   PaxDb; Q54SZ8; -.
DR   EnsemblProtists; EAL66380; EAL66380; DDB_G0282109.
DR   GeneID; 8623412; -.
DR   KEGG; ddi:DDB_G0282109; -.
DR   dictyBase; DDB_G0282109; -.
DR   eggNOG; ENOG502SFRH; Eukaryota.
DR   HOGENOM; CLU_097982_2_0_1; -.
DR   InParanoid; Q54SZ8; -.
DR   OMA; KEGEYSH; -.
DR   PhylomeDB; Q54SZ8; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8964038; LDL clearance.
DR   PRO; PR:Q54SZ8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..142
FT                   /note="Putative phosphatidylglycerol/phosphatidylinositol
FT                   transfer protein 2"
FT                   /id="PRO_0000365590"
SQ   SEQUENCE   142 AA;  15310 MW;  B7B183049B458B1B CRC64;
     MKFYLYLSIL LILLTSTSFG DIWSNCGPNE KFKITSVSIV PDPPVKGKLI TISGSGVLGE
     NLTSGQVAIL VKFGLITLIN EKKDICTLPG SPYKCPIKEG EYSHTINFTI PEAAPNGKYT
     GHVSVTDQES SEIACIDVTL TL