ID   NPC23_DICDI             Reviewed;         151 AA.
AC   Q54KP7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Putative phosphatidylglycerol/phosphatidylinositol transfer protein 3;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0287185;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000098; EAL63867.1; -; Genomic_DNA.
DR   RefSeq; XP_637383.1; XM_632291.1.
DR   AlphaFoldDB; Q54KP7; -.
DR   SMR; Q54KP7; -.
DR   STRING; 44689.DDB0215771; -.
DR   PaxDb; Q54KP7; -.
DR   EnsemblProtists; EAL63867; EAL63867; DDB_G0287185.
DR   GeneID; 8626007; -.
DR   KEGG; ddi:DDB_G0287185; -.
DR   dictyBase; DDB_G0287185; -.
DR   HOGENOM; CLU_097982_2_1_1; -.
DR   InParanoid; Q54KP7; -.
DR   OMA; YSIRCKM; -.
DR   PhylomeDB; Q54KP7; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8964038; LDL clearance.
DR   PRO; PR:Q54KP7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..151
FT                   /note="Putative phosphatidylglycerol/phosphatidylinositol
FT                   transfer protein 3"
FT                   /id="PRO_0000365591"
SQ   SEQUENCE   151 AA;  17108 MW;  5F4EEF23BA01AB60 CRC64;
     MKYSQNQIVY VIFFFIILIV VKPIESVEWS DCSDPSDSFK IEKLEFSPEQ PIAGQDLIIS
     VSGYLNKEIT KGEAYLAITF DRIPILKLKG NLCDGMGVTC PIPQGNYSTT TINQEIPENV
     PQGYYYVNFV LYDQDDLQIT CVDVQMNITQ S