ID   NPC2_ARTBC              Reviewed;         174 AA.
AC   D4AYQ6;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein {ECO:0000250|UniProtKB:O94183};
DE            Short=PG/PI-TP {ECO:0000250|UniProtKB:O94183};
DE   Flags: Precursor;
GN   ORFNames=ARB_01325;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=21919205; DOI=10.1002/pmic.201100234;
RA   Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B.,
RA   Staib P., Neuhaus J.M., Quadroni M., Monod M.;
RT   "Identification of novel secreted proteases during extracellular
RT   proteolysis by dermatophytes at acidic pH.";
RL   Proteomics 11:4422-4433(2011).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol (By similarity).
CC       {ECO:0000250|UniProtKB:O94183}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:O94183}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O94183}.
CC       Cytoplasmic vesicle {ECO:0000250|UniProtKB:O94183}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:O94183}. Secreted {ECO:0000269|PubMed:21919205}.
CC       Note=Also associated with Golgi-like vesicles.
CC       {ECO:0000250|UniProtKB:O94183}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; ABSU01000019; EFE31726.1; -; Genomic_DNA.
DR   RefSeq; XP_003012366.1; XM_003012320.1.
DR   AlphaFoldDB; D4AYQ6; -.
DR   SMR; D4AYQ6; -.
DR   STRING; 663331.D4AYQ6; -.
DR   EnsemblFungi; EFE31726; EFE31726; ARB_01325.
DR   GeneID; 9520015; -.
DR   KEGG; abe:ARB_01325; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_097982_0_0_1; -.
DR   OMA; QTYDLCE; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; Lipid transport;
KW   Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..36
FT                   /evidence="ECO:0000250|UniProtKB:O94183"
FT                   /id="PRO_0000434776"
FT   CHAIN           37..174
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_5003054104"
SQ   SEQUENCE   174 AA;  18725 MW;  ECB119090621DA9A CRC64;
     MRFSSTALIA LLLSPLALAA PPSLFRDTSQ IPLDTDGDLK VPGDNPLMYC ADPSENLLQI
     ERVDLSPNPP LPGQPLVIKA SGITAKEIKK GATVQLQVTY GFLQLINQEM DLCDQTEKVG
     LDCPLEKGKM VLKKSVDIPP QVPPGKYIVR ADVSSAEGEP ITCLTATVVF EIKV