ID   NPC2_ASHGO              Reviewed;         213 AA.
AC   Q756Q3;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=NPC2; OrderedLocusNames=AER201C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52882.1; -; Genomic_DNA.
DR   RefSeq; NP_985058.1; NM_210412.1.
DR   AlphaFoldDB; Q756Q3; -.
DR   SMR; Q756Q3; -.
DR   STRING; 33169.AAS52882; -.
DR   EnsemblFungi; AAS52882; AAS52882; AGOS_AER201C.
DR   GeneID; 4621268; -.
DR   KEGG; ago:AGOS_AER201C; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_097982_0_0_1; -.
DR   InParanoid; Q756Q3; -.
DR   OMA; RRFDVCE; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000328; C:fungal-type vacuole lumen; IEA:EnsemblFungi.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:EnsemblFungi.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   Gene3D; 2.70.220.10; -; 1.
DR   InterPro; IPR036846; GM2-AP_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..37
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019873"
FT   CHAIN           38..213
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000019874"
SQ   SEQUENCE   213 AA;  24053 MW;  4D4FD4E58F6CAA8D CRC64;
     MRVSVWYGLL HAAAWTRAVS LQVSEDSDEQ WTVALRDSRP IPGGSPLSRC DLDEDHLLDV
     QEIEITPNPP HRGKNLTVEA RGDLFGPVED GAYVTVEVRL GYIKLLSETF DLCKELEEND
     LGLQCPLEEG EYELSKTVEI PQQVPPGRYH VVARAYTVDD EPITCLTGDV YFPPLMPAER
     SRMPRLIDPR RMRRLMDPRR KPRIMDEGSG AAA