ID   NPC2_ASPFU              Reviewed;         175 AA.
AC   Q4X136;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=npc2; ORFNames=AFUA_2G11340;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL93429.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000001; EAL93429.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_755467.1; XM_750374.1.
DR   AlphaFoldDB; Q4X136; -.
DR   SMR; Q4X136; -.
DR   STRING; 746128.CADAFUBP00002649; -.
DR   GeneID; 3512803; -.
DR   KEGG; afm:AFUA_2G11340; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_097982_0_0_1; -.
DR   InParanoid; Q4X136; -.
DR   OrthoDB; 1548356at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..37
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019871"
FT   CHAIN           38..175
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000019872"
SQ   SEQUENCE   175 AA;  19083 MW;  28075216FF49F176 CRC64;
     MKLISTAATL FVCLAPLSAS ARSISFFDST QAPIQLETFP VKGDNPLVYC SDPSGNILQI
     ESVDLVPNPP LPGQTLSINA SGNLKERVEE GAYVALEVKY GLITLIKQTA DLCEQIKNVD
     LECPLEKGEM TLTKQVDLPS HIPPGKYNVH ADVYTKDGKK ITCLDAHDIE FKIRP