ID   NPC2_CANAL              Reviewed;         192 AA.
AC   Q5A8A2; A0A1D8PRW8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=NPC2; OrderedLocusNames=CAALFM_CR01280CA;
GN   ORFNames=CaO19.10736, CaO19.3226;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW30889.1; -; Genomic_DNA.
DR   RefSeq; XP_717917.2; XM_712824.2.
DR   AlphaFoldDB; Q5A8A2; -.
DR   SMR; Q5A8A2; -.
DR   STRING; 237561.Q5A8A2; -.
DR   GeneID; 3640400; -.
DR   KEGG; cal:CAALFM_CR01280CA; -.
DR   CGD; CAL0000192697; orf19.10736.
DR   VEuPathDB; FungiDB:CR_01280C_A; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_097982_0_1_1; -.
DR   InParanoid; Q5A8A2; -.
DR   OrthoDB; 1548356at2759; -.
DR   PRO; PR:Q5A8A2; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0000328; C:fungal-type vacuole lumen; IEA:EnsemblFungi.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:EnsemblFungi.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..56
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019875"
FT   CHAIN           57..192
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000019876"
SQ   SEQUENCE   192 AA;  21197 MW;  F2E54ED6442788EF CRC64;
     MVSFKNLAIV TLAVTTTSVE GISFSNIYLN KAITIFKNPT SLIPSFSNSK LINYQNTKPI
     PGDSPIEVCD ASEKQLLHLD EVIVTPNPPV AGQNLTFTAV GTLDKTIEEG AYVEVEVRYG
     FIKLIHQTYD LCEEIVKVDL QCPIKSGKQT ITKNVEIPEE VPPGKYLVVA RAYTKDDEYI
     TCLTATIIFP VQ