ID   NPC2_CRYNB              Reviewed;         180 AA.
AC   P0CP29; Q55TL6; Q5KIR9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=NPC2; OrderedLocusNames=CNBD4370;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL21061.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AAEY01000021; EAL21061.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_775708.1; XM_770615.1.
DR   AlphaFoldDB; P0CP29; -.
DR   SMR; P0CP29; -.
DR   EnsemblFungi; AAW42927; AAW42927; CND01990.
DR   EnsemblFungi; EAL21061; EAL21061; CNBD4370.
DR   GeneID; 4935826; -.
DR   KEGG; cnb:CNBD4370; -.
DR   HOGENOM; CLU_097982_3_0_1; -.
DR   Proteomes; UP000001435; Chromosome 4.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   Gene3D; 2.70.220.10; -; 1.
DR   InterPro; IPR036846; GM2-AP_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..43
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000410171"
FT   CHAIN           44..180
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000410172"
SQ   SEQUENCE   180 AA;  19320 MW;  87EE908D6BF62BD3 CRC64;
     MKLAPFLIPF IATTVTASLA GEALSWAGQL VGGGRGALAT GDGPVRTENS WSYVDCGLAT
     DAIQLKSIKV HPDPPVPGKN LTVTVEGDVL ETIEEGAYVD VTVKLGLIKL LQKEFDVCDE
     ARHANASVQC PVQPGPYTVT ETVELPQEIP KAKFSVLVRG YTVDDEDMVC LDLFVDFMKK