ID   NPC2_NEUCR              Reviewed;         177 AA.
AC   Q7RZ85;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=npc-2; ORFNames=29E8.270, NCU04388;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; BX908809; CAF06060.1; -; Genomic_DNA.
DR   EMBL; CM002239; EAA28229.1; -; Genomic_DNA.
DR   RefSeq; XP_957465.1; XM_952372.3.
DR   AlphaFoldDB; Q7RZ85; -.
DR   SMR; Q7RZ85; -.
DR   STRING; 5141.EFNCRP00000005222; -.
DR   EnsemblFungi; EAA28229; EAA28229; NCU04388.
DR   GeneID; 3873619; -.
DR   KEGG; ncr:NCU04388; -.
DR   VEuPathDB; FungiDB:NCU04388; -.
DR   HOGENOM; CLU_097982_0_0_1; -.
DR   InParanoid; Q7RZ85; -.
DR   OMA; QTYDLCE; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0000328; C:fungal-type vacuole lumen; IEA:EnsemblFungi.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:EnsemblFungi.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..30
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019889"
FT   CHAIN           31..177
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000019890"
SQ   SEQUENCE   177 AA;  19341 MW;  49FE490B56B5CCD1 CRC64;
     MRLSAAVIAL LSTSAAAFSV YRENSVSAND ELDVPGKSPL RFCDAAADRK DDIVTIEEVI
     LTPNPPEAGQ TLTIEASGIV KEAIEEGAYV NLQVKYGYIR LINTSADLCK EMKNVELECP
     IKKGRLSITK NVELPKEIPP GKYTVEADVY NSDDKHITCL TATVFFGRKT LGFLDDL