NPC2_SCHPO
ID NPC2_SCHPO Reviewed; 188 AA.
AC Q9C0X9;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE Short=PG/PI-TP;
DE Flags: Precursor;
GN Name=npc2; ORFNames=SPAPB8E5.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC and phosphatidylinositol. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAC37423.1; -; Genomic_DNA.
DR RefSeq; NP_594778.1; NM_001020206.2.
DR AlphaFoldDB; Q9C0X9; -.
DR SMR; Q9C0X9; -.
DR BioGRID; 279755; 16.
DR STRING; 4896.SPAPB8E5.04c.1; -.
DR MaxQB; Q9C0X9; -.
DR PaxDb; Q9C0X9; -.
DR EnsemblFungi; SPAPB8E5.04c.1; SPAPB8E5.04c.1:pep; SPAPB8E5.04c.
DR GeneID; 2543332; -.
DR KEGG; spo:SPAPB8E5.04c; -.
DR PomBase; SPAPB8E5.04c; npc2.
DR VEuPathDB; FungiDB:SPAPB8E5.04c; -.
DR eggNOG; KOG4680; Eukaryota.
DR HOGENOM; CLU_097982_0_0_1; -.
DR InParanoid; Q9C0X9; -.
DR OMA; RRFDVCE; -.
DR PhylomeDB; Q9C0X9; -.
DR PRO; PR:Q9C0X9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000328; C:fungal-type vacuole lumen; ISO:PomBase.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0032366; P:intracellular sterol transport; ISO:PomBase.
DR GO; GO:0061024; P:membrane organization; IC:PomBase.
DR GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR CDD; cd00917; PG-PI_TP; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR033917; ML_PG-PI_TP.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; PTHR11306; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Lipid transport; Reference proteome; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..40
FT /evidence="ECO:0000250"
FT /id="PRO_0000019891"
FT CHAIN 41..188
FT /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT protein"
FT /id="PRO_0000019892"
SQ SEQUENCE 188 AA; 20531 MW; 6B995E25E8D685FE CRC64;
MRLTTFIYAI TCLPIFISAS SWFSSFSFGE SKSTDLVSST SEKIPGANPA SYCADWDRGD
DHVVVDYINL IPNPPAAGKN LTIETEINVG TTVLNGSYVD IQVKYGFVRI VNERLDICDK
AYELAAVECP VEPGIITKQA TISLPWAIPP GRYHVLATAY NADGEQLTCV SASVSFSHFG
FQLINQDH
