NPC2_USTMA
ID NPC2_USTMA Reviewed; 193 AA.
AC Q4P580; A0A0D1DW04;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE Short=PG/PI-TP;
DE Flags: Precursor;
GN Name=NPC2; ORFNames=UMAG_04733;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC and phosphatidylinositol. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR EMBL; CM003156; KIS66670.1; -; Genomic_DNA.
DR RefSeq; XP_011391615.1; XM_011393313.1.
DR AlphaFoldDB; Q4P580; -.
DR SMR; Q4P580; -.
DR STRING; 5270.UM04733P0; -.
DR EnsemblFungi; KIS66670; KIS66670; UMAG_04733.
DR GeneID; 23564819; -.
DR KEGG; uma:UMAG_04733; -.
DR VEuPathDB; FungiDB:UMAG_04733; -.
DR eggNOG; KOG4680; Eukaryota.
DR HOGENOM; CLU_097982_3_0_1; -.
DR InParanoid; Q4P580; -.
DR OMA; RRFDVCE; -.
DR OrthoDB; 1548356at2759; -.
DR Proteomes; UP000000561; Chromosome 17.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR CDD; cd00917; PG-PI_TP; 1.
DR Gene3D; 2.70.220.10; -; 2.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR033917; ML_PG-PI_TP.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; PTHR11306; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Lipid transport; Reference proteome; Signal; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..54
FT /evidence="ECO:0000250"
FT /id="PRO_0000019893"
FT CHAIN 55..193
FT /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT protein"
FT /id="PRO_0000019894"
SQ SEQUENCE 193 AA; 20795 MW; 236A6F70E1BB2A97 CRC64;
MHSRFIAVTL ASLSLASQAV AWGCIGQDCN QAADQIAFSA PEPASYEGKV KSLAWEPTPG
QGWQWSSCGT GDEVVNVESI VVSPDPPVPG QNLTVRAKGT VKDEVSDGTF ADVIVKLGLI
RLLARRFDVC EQARESNADL QCPLSAGEYE LEHTVALPRE IPPGKFNVHI TGENQDGSNL
LCLDLSIQFG FRR