ID   NPC2_YARLI              Reviewed;         189 AA.
AC   Q6CHU5;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein;
DE            Short=PG/PI-TP;
DE   Flags: Precursor;
GN   Name=NPC2; OrderedLocusNames=YALI0A04895g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; CR382127; CAG83691.1; -; Genomic_DNA.
DR   RefSeq; XP_499766.1; XM_499766.1.
DR   AlphaFoldDB; Q6CHU5; -.
DR   SMR; Q6CHU5; -.
DR   STRING; 4952.CAG83691; -.
DR   EnsemblFungi; CAG83691; CAG83691; YALI0_A04895g.
DR   GeneID; 2906213; -.
DR   KEGG; yli:YALI0A04895g; -.
DR   VEuPathDB; FungiDB:YALI0_A04895g; -.
DR   HOGENOM; CLU_097982_0_1_1; -.
DR   InParanoid; Q6CHU5; -.
DR   OMA; QTYDLCE; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032366; P:intracellular sterol transport; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00917; PG-PI_TP; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033917; ML_PG-PI_TP.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..52
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019895"
FT   CHAIN           53..189
FT                   /note="Phosphatidylglycerol/phosphatidylinositol transfer
FT                   protein"
FT                   /id="PRO_0000019896"
SQ   SEQUENCE   189 AA;  20573 MW;  534A012C6980C2A1 CRC64;
     MKLSILPLIA LATAVVASPA PDANSMKLMN QAKDFGMSVA QGGLKDIAKT LDDEDIPGDS
     PISLCDAEYE QLLEIKHLSI DPNPPAKGQN LTIEASGYLY EDVEEGAYIE VEVRYGYIRL
     ISQTLDLCEQ SEQVDWSCPI KAGDLKLNKQ IELPNEIPPG KYVAVARAYT VDDDLITCLL
     TTVTFPASL